Abstracts Archive - Page 310 of 1683 - ATC Abstracts

2021 American Transplant Congress
Complement Blockade Improves Renal Xenograft Survival in Primates in the Absence of Transgenic Complement Regulatory Proteins
D. A. Faber¹, B. Lovasik¹, A. Matar¹, C. Breeden¹, A. B. Farris², M. Tector³, A. Tector³, A. Adams⁴
¹Surgery, Emory University School of Medicine, Atlanta, GA, ²Pathology, Emory University School of Medicine, Atlanta, GA, ³Surgery, University of Miami, Miami, FL, ⁴Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Complement activation is a major contributor to xenograft rejection. To minimize xenograft injury, complement suppression via insertion of human complement-regulatory transgenes into the donor…
2021 American Transplant Congress
Outcomes of Hepatitis C Nucleic Acid Testing Positive Donors in Aviremic Recipients With Delayed Direct-Acting Antiviral Initiation
M. Hudson, A. Webb, A. Logan, A. Silverman, A. Brueckner
Pharmacy, Tampa General Hospital, Tampa, FL
*Purpose: The purpose of this study was to assess the clinical impact of utilizing hepatitis C virus (HCV) nucleic acid testing (NAT)+ donors in HCV…
2021 American Transplant Congress
Selective Regulatory T Cell Expansion by a Novel IL-2 Mutein Prolongs Skin Transplant Survival in Mice
T. J. Borges¹, O. Effe¹, R. B. Gassen¹, A. Al Jurdi¹, I. T. Lape¹, G. J. Babcock², S. M. Carlson², J. C. Madsen¹, L. V. Riella¹
¹Center For Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Visterra, Inc., Waltham, MA
*Purpose: Long-term immunosuppression predisposes transplant patients to a greater risk of infection, malignancy and kidney toxicity. Hence, alternative methods to regulate the immune system are…
2021 American Transplant Congress
Outcomes of Short-Duration Anti-Viral Prophylaxis for Hepatitis C Positive Donor Kidney Transplants
G. Gupta, I. Yakubu, P. Kimball, L. Kang, K. Mitchell, M. Shinbashi, D. Kumar, I. Moinuddin, L. Kamal, A. King, C. Bhati, M. Levy, A. Cotterell, A. Sharma, R. Sterling
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant…
2021 American Transplant Congress
A Cost Benefit Analysis of Different Minimal Access Donor Nephrectomy Techniques Performed at a Busy Transplant Centre
H. Sharma¹, A. Odougoudar², A. Sharma², D. Ridgway², A. Hammad², S. Mehra²
¹Transplant and Vascular Access Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom, ²Transplant and Vascular Access Surgery, Royal Liverpool Hospital, Liverpool, United Kingdom
*Purpose: We performed the cost-benefit analyses comparing Total Laparoscopic Retroperitoneoscopic donor nephrectomy (TLTLRPDN) versus Hand-assisted laparoscopic donor nephrectomy (HALDN) operations performed at our centre since…
2021 American Transplant Congress
The Australian and New Zealand Living Kidney Donor Profile Index
G. L. Irish¹, S. Chadban¹, N. Boudville², S. B. Campbell³, J. Kanellis⁴, P. A. Clayton¹
¹Australian and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, Australia, ²Medical School, University of Western Australia, Perth, Australia, ³Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia, ⁴Department of Nephrology, Monash Health, Melbourne, Australia
*Purpose: Risk scores may aid risk quantification and decision-making in kidney transplantation. The Living Kidney Donor Profile Index (LKDPI) was developed to choose between living…
2021 American Transplant Congress
Single Cell RNA Sequencing of Tim1- B Cells and Tim1+ Regulatory B Cells
Q. Fu¹, K. Lee², K. Deng², D. Agarwal³, P. v. Galen⁴, C. G. Rickert², G. Huai², H. Yang¹, C. LeGuern², S. Deng¹, J. F. Markmann²
¹Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA, ³Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁴Division of Hematology, Brigham and Women's Hospital, Boston, MA
*Purpose: Tim1 signaling has an important role in inducing and maintaining the function of Regulatory B cells. Our previous study showed that Tim1+ Bregs prolong…
2021 American Transplant Congress
Managing the Costs of Routine Follow-up Care After Living Kidney Donation: A Survey of Contemporary Experience, Practice & Challenges
K. Lentine¹, G. McNatt², R. Howey³, C. Thomas², R. Hays⁴, U. Lebron-Banks⁵, S. Ainapurapu¹, A. Tietjen⁶
¹Saint Louis University, Saint Louis, MO, ²Univ. Iowa, Iowa City, IA, ³Toyon Associates, Concord, CA, ⁴Univ. Wisconsin, Madison, WI, ⁵New York-Presbyterian Hosp., New York, NY, ⁶St. Barnabas, Livingston, NJ
*Purpose: Organ Procurement and Transplantation Network (OPTN) Policy mandates that living kidney donor (LKD) programs collect and report clinical and laboratory follow-up information for living…
2021 American Transplant Congress
Allograft Function and Baseline Donor Derived Cell Free DNA in Kidney Transplant Recipients: One Size Doesn’t Fit All
K. K. Sureshkumar, A. Grazier, B. Chopra
Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA
*Purpose: Donor derived cell free DNA (dd-cfDNA) is increasingly used to predict acute rejection in kidney allografts . Cell free DNA fragments are constantly released…
2021 American Transplant Congress
Launching a National Living Donor Registry
J. E. Milton¹, M. Cooper², B. Hippen³
¹Transplant Center, University of Texas Health San Antonio, San Antonio, TX, ²MedStar Georgetown Transplant Institute, Washington, Colombia, ³Metrolina Nephrology Associates, PA, Charlotte, NC
*Purpose: The National Donate Life Living Donor Registry launching in 2021 will allow 4000 persons a day the opportunity to become a living donor offering…