2016 American Transplant Congress
Exposure Analysis for the Composite Efficacy Endpoints in the US92 Phase 3 Kidney Transplantation Trial to Understand Center Effects.
The US92 study determined whether, in de novo renal transplant patients, concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®, (mycophenolate…2016 American Transplant Congress
Comparison of Pharmacokinetic and Clinical Outcomes of Tacrolimus Hexal® with Prograf® Based Regimen in De Novo Kidney Transplant Recipients: Results from the Randomized, SparTacus Study.
1SparTacus Study Group, Cologne, Germany; 2Novartis Pharma GmbH, Nuernberg, Germany.
Background: There is very limited evidence on the pharmacokinetic (PK) and clinical outcomes, comparing a generic tacrolimus with the standard reference drug in transplant (Tx)…2016 American Transplant Congress
Clinical Outcome in Pure T-Cell Mediated Acute Rejection of the Kidney with No Donor Specific Antibody or C4d Staining.
Background: T-cell mediated rejection (TCMR) is now considered to have little impact on renal graft function. This study re-evaluated the histologic phenotypes and clinical significance…2016 American Transplant Congress
Acute Allograft Glomerulopathy: A Distinct Form of Cellular Rejection.
Background: Acute allograft glomerulopathy (AAG) is an unusual glomerular lesion of allografts with endocapillary hypercellularity, markedly enlarged endothelial cells occluding the capillary lumen, and absence…2016 American Transplant Congress
The Impact of Treating Borderline Cellular Rejections.
Introduction: Histological findings that meet the criteria for Borderline rejection (BR) as defined by the Banff Classification are frequently seen. The clinical significance of a…2016 American Transplant Congress
Urine-Derived Cell Lines as a Novel Tool for Monitoring Allo-Reactivity in Kidney Transplant Patients.
Reactivity of the immune system against donor antigens determines transplant-rejection after transplantation, and analyzing the alloimmune response has been shown to predict acute rejection in…2016 American Transplant Congress
Transcriptome Profiles in Peripheral Blood of Kidney Graft Recipients.
The discovery of sensitive noninvasive diagnosis and the development of immune management in the renal allograft recipients are required for long-term graft survival. Although the…2016 American Transplant Congress
The Impact of Allograft Rejection on DNA Methylation After Kidney Transplantation.
ErasmusMC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Introduction DNA methylation is a well-known epigenetic mechanism which plays a critical role in cell function by regulating gene expression. Variations in DNA methylation are…2016 American Transplant Congress
Cytokine Networks in Kidney Transplant Patients.
As key mediators of the intercellular communication, cytokines play a crucial role in many processes following transplantation, including inflammation, tissue regeneration, and anti-microbial defense. Locally…2016 American Transplant Congress
The Urine Common Rejection Module (uCRM) Is a Sentinal Assay for Graft Rejection.
1Surgery, UCSF, San Francisco, CA; 2Nephrology, Bellevitage Hospital, Barcelona, Spain.
Background: A common rejection module (CRM) consisting of 11 genes are expressed in solid organ transplant rejection in kidney, heart, liver and lung transplantation (Khatri,…
American Transplant Congress abstracts