Abstracts Archive - Page 1129 of 1683 - ATC Abstracts

2017 American Transplant Congress
Analysis of ApoL1 and MYH9 Genetic Polymorphisms Among the Hispanic Kidney Allograft Recipients.
Y. Chang,^1,2 T. Shah,^1,3 D. Min.¹
¹Western University of Health Sciences, Pomona, CA; ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA; ³St. Vincent Medical Center, Los Angeles, CA
Introduction: Genetic polymorphisms of Apolipoprotein 1 (ApoL1) and non-muscle heavy chain 9 (MYH9) genes are known to be strongly associated with focal segmental glomerulosclerosis, HIV-associated…
2017 American Transplant Congress
The Immunophenotype of Peritubular Capillaritis in Renal Transplant Biopsies.
T. Chen,¹ L. Rasch,¹ T. Al Johani,² H. McPhail,¹ M. Willicombe,³ A. McLean,³ J. Galliford,³ T. Cook,¹ C. Roufosse.¹
¹Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; ²Cellular Pathology, King Saud University, Riyadh, Saudi Arabia; ³Dept Renal Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom
Background: Peritubular capillaritis (ptc) is a feature of acute antibody-mediated rejection (ABMR) in the renal allograft. However, it is not an specific feature for ABMR…
2017 American Transplant Congress
Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.
P. Saravanan,¹ J. Gu,¹ X. Wang,¹ P. Nguyen,¹ G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott and White Research Institute, Dallas, TX; ²Baylor Simmons Transplant Institute, Dallas, TX
Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…
2017 American Transplant Congress
CXCL13 as a New Systemic Biomarker for B-Cell Involvement in Acute Kidney Allograft Rejection.
L. Schiffer,¹ F. Wiehler,¹ M. Daemmrich,² K. Hueper,³ M. Mengel,⁴ A. Thorenz,¹ S. von Vietinghoff,¹ R. Song,¹ M. Schiffer,¹ F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, Hannover Medical School, Hannover, Germany; ³Radiology, Hannover Medical School, Hannover, Germany; ⁴Laboratory Medicine & Pathology, University of Alberta, Edmonton, Canada
The majority of kidney allograft rejections are T cell mediated (TCMR). However, it has been shown that in the presence of B-cell clusters the course…
2017 American Transplant Congress
Imaging Cell Biology in Transplantation.
T. Ueno,¹ M. McGrath,¹ M. Yeung,¹ K. Jung,² Y. Kihara,³ O. Konno,³ Y. Nakamura,³ H. Iwamoto,³ S. Yun,² A. Chandraker.¹
¹Transplantation Research Center, Brighma and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan
Background: Following transplantation, a set of coordinated events occurs within the recipient immune system. Immature dendritic cells (DCs) migrate to sites of inflammation, become activated…
2017 American Transplant Congress
Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function.
H. Wadei,¹ J. Belcher,² C. Parikh,² T. Gonwa,¹ M. Mai,¹ J. Lieske.³
¹Transplant, Mayo Clinic, Jacksonville, FL; ²Medicine, Section of Nephrology, Yale University, New Haven, CT; ³Medicine, Division of Nephrology, Mayo Clinic, Rochester, MN
UBio might be valuable in determining the etiology of renal dysfunction in LT candidates.Aim: Correlate UBio with pre-LT kidney biopsy and post-LT kidney function.Methods:78 LT…
2017 American Transplant Congress
Performance Comparison of Barcoded Oligos and Standard qPCR on Matched FFPE and RNAlater-Submerged Human Kidney Allograft Samples.
T. Sigdel, M. Nguyen, D. Dobi, J. Liberto, S.-C. Hsieh, F. Vincenti, M. Sarwal, Z. Laszik.
University of California, San Francisco, San Francisco
Background: Gene expression profiling can improve the diagnostic ability of kidney allograft injury. Fresh tissue is the favored study material for transcriptomic analysis due to…
2017 American Transplant Congress
Mechanistic Insights by RNA Profiling on Rejecting Vascularized Composite Allotransplants.
H.-Y. Cheng,¹ S.-C. Liu,² C.-F. Lin,¹ L.-Y. Shih,³ F.-C. Wei.^1,2,3
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; ²College of Medicine, Chang Gung University, Taoyuan, Taiwan; ³Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Background: Detailed molecular changes associated with rejection to vascularized composite allotransplants (VCA) are not well understood. Materials and Methods: peripheral blood was drawn from the…
2017 American Transplant Congress
Omega 3 Attenuates Ischemia Reperfusion Renal Injury via Enhancement of Autophagy Flux.
J.-J. Kim,¹ J. Jeong,² D. Choi,³ K. Na,³ K. Lee.³
¹Chungnam National University, Anatomy, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea; ³Chungnam National University, Nephrology, Daejeon, Korea
Purpose: Omega 3 fatty acid showed the protective effect against various renal injuries. Recently, it is reported that Omega 3 regulates the autophagy. Using fat-1…
2017 American Transplant Congress
Protective Effect of New Delivery System of Nitric Oxide Releasing Nanofiber in Rat Model of Renal Ischemia-Reperfusion Injury.
J. Kim,¹ H. Ahn,² D. Kim,¹ S. Jung,¹ E. Park,¹ T. Lee,¹ C. Ihm,¹ S. Lee,¹ J. Moon,¹ Y. Kim,¹ K. Jeong.¹
¹Nephrology, Kyung Hee University Medical Center, Seoul, Korea; ²Surgery, Kyung Hee University Medical Center, Seoul, Korea
Objective: Renal ischemia-reperfusion injury (IRI) is very important in various clinical setting including kidney transplantation. Nitric oxide (NO) is well known for having various protective…