ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Non-Renal Factors Predicting Combined Liver-Kidney Transplantation for Non-Dialysis-Requiring Wait-Listed End Stage Liver Disease Patients: 14 Years of US Experience.

A. Santos, M. Casey, K. Alquadan, J. Gregg, K. Womer.

University of Florida, Gainesville, FL

Meeting: 2017 American Transplant Congress

Abstract number: 431

Keywords: Glomerular filtration rate (GFR), Kidney/liver transplantation, Liver transplantation

Session Information

Date: Tuesday, May 2, 2017

Session Name: Concurrent Session: Kidney Issues in Liver Transplantation

Session Time: 2:30pm-4:00pm

 Presentation Time: 3:42pm-3:54pm

Location: E451b

Related Abstracts
  • Clinical Results of Combined and Sequential Liver-Kidney Transplantation: A Single Center Experience
  • Rapid Deterioration of Pre-Transplant Kidney Function Requiring Dialysis Is a Prognostic Factor in Liver Transplant Alone.

OBJECTIVE: We aimed to identify the non-renal factors associated with the higher likelihood of combined liver-kidney transplantation (CLKT) vs. liver transplantation alone (LTA) in end stage liver disease (ESLD) patients not requiring dialysis (NOD) or qualified for preemptive kidney transplant alone at the time of wait-listing for liver transplant.

PATIENTS AND METHODS: Based on OPTN data as of March 31,2016, we studied adult ESLD patients wait-listed for liver transplant in July 2002-March 2016 with modification of diet in renal disease (MDRD) equation-estimated glomerular filtration rate (GFR) of >20 ml/min and NOD. The outcome of the study was CLKT or LTA. Patients who had not received a CLKT or LTA after wait-listing, died on the wait-list, received other (except renal) organ or a living donor liver transplant, or received dialysis in the wk. before CLKT or LTA were excluded from the analysis. We used logistic regression analysis to determine odds ratio and 95% confidence interval for CLKT vs. LTA associated with risk factors.

RESULTS: Out of 31,072 liver transplant candidates, MDRD- GFR was >30 ml/min. in 28,988 (93.3%) and <30 ml/min. in 2084 (6.7%) at LT wait-listing. At the time of CLKT or LTA, MDRD-GFR was >30 ml/min in 26,152 (84.2%) and <30 ml/min in 4,897 (15.8%) patients: CLKT rates were 1.38% (n=361) and 16.8% (n=823); respectively.

The strongest predictors of CLKT vs. LAT were: MDRD-GFR at both wait-listing and transplant and MELD score at transplant. In decreasing point estimates, the non-renal risk factors for CLKT vs. LTA were: wait-list duration; previous liver transplant; recipient history of diabetes, African American ethnicity, age >65 yr., need for life support, Hispanic ethnicity and age 50-64 yr.; and transplant era, 2009-2016. The likelihood of CLKT vs. LTA was lower with: donor age and liver transplant volume in the hospital-venue of CLKT or LAT (Figure 1).CONCLUSION: Aside from MELD score and MDRD-GFR, there are significant non-renal risk factors associated with higher likelihood of CLKT vs. LTA in non-dialysis-requiring liver transplant candidates.

CITATION INFORMATION: Santos A, Casey M, Alquadan K, Gregg J, Womer K. Non-Renal Factors Predicting Combined Liver-Kidney Transplantation for Non-Dialysis-Requiring Wait-Listed End Stage Liver Disease Patients: 14 Years of US Experience. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Santos A, Casey M, Alquadan K, Gregg J, Womer K. Non-Renal Factors Predicting Combined Liver-Kidney Transplantation for Non-Dialysis-Requiring Wait-Listed End Stage Liver Disease Patients: 14 Years of US Experience. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/non-renal-factors-predicting-combined-liver-kidney-transplantation-for-non-dialysis-requiring-wait-listed-end-stage-liver-disease-patients-14-years-of-us-experience/. Accessed February 27, 2021.

« Back to 2017 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.