Long-Term Outcomes Among Slow versus Delayed or Immediate Graft Function Kidney Transplant Recipients: A Single-Center Experience.
Transplant Institute, Henry Ford Health System, Detroit, MI
Meeting: 2017 American Transplant Congress
Abstract number: B153
Keywords: Graft function, Graft survival, Kidney transplantation, Mortality
Session Information
Session Name: Poster Session B: Kidney Complications II
Session Type: Poster Session
Date: Sunday, April 30, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Purpose: To compare and evaluate short and long-term outcomes for kidney transplant recipients (KTR) with slow graft function (SGF) versus delayed (DGF) or immediate (IGF) graft function.
Introduction: KTR who experience DGF exhibit worse outcomes than other KTR; however there is a subset of patients who do not require dialysis post-transplant, but have slower graft recovery. This novel analysis provides new data on outcomes for this sub-population.
Methods: A single-center retrospective analysis of medical records of 352 KTR from 2012-2015 was performed. Study population was divided into three cohorts: IGF (n=174), SGF (n=83), and DGF (n=95). IGF is defined as KTR with a serum creatinine (SCr) <3mg/dL; SGF is defined as KTR with a SCr ≥3mg/dL at post-operative day (POD) 5; and DGF is defined as a KTR requiring dialysis within the first 7 POD. All African Americans (AA), KTR of ECD/DCD kidneys, repeat kidney transplants, and cPRA>20% received thymo induction. Demographics, 1yr biopsy-proven rejection (BPAR), as well as SCr and eGFR at point of last follow-up (FU) post-transplant were analyzed.
Results: There was no overall statistical difference between the three groups' genders or ages. For other results, please refer to Table 1.
| Table 1 | IGF
n=174 |
SGF
n=83 |
DGF
n=95 |
IGF vs SGF | DGF vs SGF |
| AA | 29.89% | 46.99% | 64.21% | p<0.05 | NS |
| Hospital LOS (days) | 5±3.47 | 4.5±2.89 | 7±3.86 | NS | p<0.01 |
| ICU | 22.99% | 16.87% | 38.95% | NS | p<0.05 |
| SCr FU (mg/dL) | 1.3±0.53 | 1.45±0.67 | 1.55±1.03 | p<0.01 | NS |
| eGFR FU (mL/min/1.73 m2) | 60.05±22.76 | 52.91±20.09 | 51.87±22.59 | p<0.01 | NS |
| Median FU (days) | 1062±397.58 | 1046.5±321.30 | 866±369.29 | NS | p<0.05 |
| NS: not statistically significant (p>0.05)
Median±Standard Deviation |
|||||
DGF and SGF had a similar number of patients who received thymo induction (DGF, 64.21%; SGF, 67.47%; p>0.05), but both statistically higher than IGF (44.83%; p<0.05). In addition, DGF and SGF also had similar rates of BPAR at 1yr (DGF, 11.59%; SGF, 9.64%; p>0.05), but both statistically higher than IGF (8.05%; p<0.05).
Conclusion: In our analysis, we found that the SGF patients behaved similarly to the DGF than the IGF population, long-term. Therefore, consideration must be made to these potentially high-risk patients.
CITATION INFORMATION: Bajjoka I, Yaldo A, Crombez C, Abouljoud M. Long-Term Outcomes Among Slow versus Delayed or Immediate Graft Function Kidney Transplant Recipients: A Single-Center Experience. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Bajjoka I, Yaldo A, Crombez C, Abouljoud M. Long-Term Outcomes Among Slow versus Delayed or Immediate Graft Function Kidney Transplant Recipients: A Single-Center Experience. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/long-term-outcomes-among-slow-versus-delayed-or-immediate-graft-function-kidney-transplant-recipients-a-single-center-experience/. Accessed November 21, 2024.« Back to 2017 American Transplant Congress