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Locoregional Therapy and Long-Term Post-Transplant Outcomes for HCC Liver Transplant Recipients

T. Ishaque, S. R. Weeks, A. Kolarich, J. Ruck, J. Garonzik-Wang, D. Segev, A. Massie, B. King

Johns Hopkins Medical Institutions, Baltimore, MD

Meeting: 2022 American Transplant Congress

Abstract number: 1093

Keywords: Graft failure, Hepatocellular carcinoma, Liver, Mortality

Topic: Clinical Science » Liver » 56 - Liver: Hepatocellular Carcinoma and Other Malignancies

Session Information

Session Name: Liver: Hepatocellular Carcinoma and Other Malignancies

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: In last decade, locoregional therapy (LRT) have been widely used to downstage HCC patients in order to qualify for liver transplantation. Large-scale direct comparisons of long-term post-transplant outcome for LRT and non-LRT recipients are lacking. We sought to investigate the association between LRT and post-transplant outcome in HCC liver transplant recipients using nationwide SRTR data.

*Methods: Using SRTR data January 2010-May 2021, we identified 17487 adult, first-time deceased donor liver transplant (DDLT) recipients who were granted HCC exception points. We compared all-cause graft failure (death or re-transplant) between LRT and non-LRT recipients using multivariate Cox regression in three separate groups: recipients with single tumor ≤3 cm, single tumor >3 cm and multiple tumors.

*Results: Among HCC recipients with single tumor ≤3 cm, ten-year graft failure rate for LRT and non-LRT recipients were 35.9% vs. 37.5%; after adjustment, LRT recipients had 10% lower graft failure rate compared to non-LRT recipients (aHR=0.82 0.90 0.99). Among HCC recipients with single tumor >3 cm, ten-year graft failure rate for LRT and non-LRT recipients were 44.9% vs. 40.3%; after adjustment, LRT recipients had 18% higher graft failure rate compared to non-LRT recipients (aHR= 1.00 1.18 1.39). Among HCC recipients with multiple tumors, ten-year graft failure rate for LRT and non-LRT recipients were 39.2% vs. 37.4%; after adjustment, there was no evidence of association between the LRT and graft failure (aHR= 0.87 0.99 1.14).

*Conclusions: Even after receiving LRT, HCC recipients with advanced tumor had similar or higher risk of graft failure compared to non-LRT recipients. LRT has better results in HCC recipients with small sized single tumor.

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To cite this abstract in AMA style:

Ishaque T, Weeks SR, Kolarich A, Ruck J, Garonzik-Wang J, Segev D, Massie A, King B. Locoregional Therapy and Long-Term Post-Transplant Outcomes for HCC Liver Transplant Recipients [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/locoregional-therapy-and-long-term-post-transplant-outcomes-for-hcc-liver-transplant-recipients/. Accessed May 30, 2025.

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