Live Donor Liver Transplantation Using Grafts with More Than Two Bile Ducts – Does It Affect Patient Outcome?
Multi Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
Meeting: 2017 American Transplant Congress
Abstract number: 367
Keywords: Bile duct, Liver transplantation, Living-related liver donors
Session Information
Session Name: Concurrent Session: Liver Living Donors and Partial Grafts
Session Type: Concurrent Session
Date: Monday, May 1, 2017
Session Time: 4:30pm-6:00pm
Presentation Time: 4:42pm-4:54pm
Location: E451a
Introduction: It's been described that the use of live donor (LD) liver grafts with multiple bile ducts (BD) increases the risk of BD related complications after live donor liver transplantation (LDLT). We aim to evaluate the impact of multiple BD in LD grafts on the outcome following LDLT.
Methods: From 2000-2015, 510 LDLT were performed at our institution. Outcome of patients receiving a LDLT using grafts with ≥2 BD (n=190) were compared to all patients receiving a LD graft with only one BD (n=320).
Results: Demographic variables and disease severity was equally distributed between both groups. Roux-y reconstruction of the BD was significantly higher in the ≥2 BD group (n=148, 77.9%) when compared to those patients receiving a graft with a single BD (n=123, 38.6%; p<0.001). Biliary complication rate after LDLT was not different between both groups (1 BD: 75 (23.4%) vs. ≥2 BD: 43 (22.6%); p=0.914). Recipients major complication (Clavien ≥3b) rate was similar between both groups (1 BD: 41.6% vs. ≥2 BD: 44.7%; p=0.517), and both groups had a comparable re-transplantation rate (1 BD: 18 (5.6%) vs. ≥2 BD: 11 (5.8%), p=1). The 1-(90% vs. 91%), 5- (82% vs. 78%), and 10-year (70% vs. 68%) graft survival was comparable between the single and the multiple BD groups (p=0.588). Likewise, there was no significant difference in the 1-, 5- and 10-year patient survival between both groups (1 BD: 92%, 84%, 75% vs. ≥2 BD: 94%, 82%, 78%, respectively; p=0.84). In addition, patients receiving a graft with 3 BD (n=18) showed similar graft survival to those with ≤2 BD (n=492) (≤2 BD: 90%, 80%, 60% vs. 3 BD: 94%, 87%, 75%; p=0.745).
Conclusion. LDLT using grafts with multiple BD is safe and does not negatively impact on postoperative biliary complication rate and graft survival.
CITATION INFORMATION: Kollmann D, Sapisochin G, Selzner N, Cattral M, Greig P, Lilly L, McGilvray I, Ganekar A, Grant D, Selzner M, Goldaracena N. Live Donor Liver Transplantation Using Grafts with More Than Two Bile Ducts – Does It Affect Patient Outcome? Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Kollmann D, Sapisochin G, Selzner N, Cattral M, Greig P, Lilly L, McGilvray I, Ganekar A, Grant D, Selzner M, Goldaracena N. Live Donor Liver Transplantation Using Grafts with More Than Two Bile Ducts – Does It Affect Patient Outcome? [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/live-donor-liver-transplantation-using-grafts-with-more-than-two-bile-ducts-does-it-affect-patient-outcome/. Accessed May 9, 2025.« Back to 2017 American Transplant Congress