Background

Kidney transplantation (KTx) is the preferred renal replacement therapy in selected individuals.There is limited data on transplantation of octogenarians. The purpose of this study was to examine our program's experience transplanting individuals in their 80's.

Methods

We searched the transplant database for patients who were >79 years of age at the time of transplant. End points were death censored graft survival and all cause graft loss. Control groups for survival analysis were patients with age groups <65 years, 65-74 years and 75-79 years. There were 11 transplants performed in octogenarians in our program. As the first octogenarian was transplanted in 2000, we censored transplants before 2000. We excluded all patients with <12 months follow-up.

Results

In our cohort of 2896 transplants, 10 (0.35%) were octogenarians, 43 (1.5%) were [75-79], 473 (16%)[65-74] and 2370 (82%)< 65 years old. Octogenarians were 80-84 years old at the time of transplant. Nine were males and 9 received a living donor KTx. Family members were donors in 7 cases. All recipients had a post graduate degree, 4 of them were physicians. Seven patients received preemptive transplants while the rest were on dialysis for <1 year. Thymoglobulin was used for induction before 2005 and basiliximab thereafter. None of the patients were diabetic. Native kidney disease was hypertensive nephrosclerosis in 9 and reflux nephropathy in one. One recipient had a non-fatal postoperative MI. Mean follow-up was 87 ± 22 [54-121] months. Median post-transplant survival was 87 months. 1 patient lost his graft from transplant glomerulopathy and 5 died from deconditioning and infections. Comparative survival is shown below.Conclusion

KTx can benefit a selected group of octogenarians. Information about good outcomes should be spread to providers and individuals to encourage transplant referrals in this patient population.

CITATION INFORMATION: Khoury N, Schwab T, Prieto M, Amer H. Kidney Transplantation in Octogenarians: The Mayo Clinic Experience. Am J Transplant. 2017;17 (suppl 3).

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