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Impact of Pre-Transplant Panel Reactive Antibody Levels On Renal Graft Survival in Patients With Negative Cross-Match and No Donor Specific Antibody

K. Jun,1 M. Kim,1 H. Kim,1 K. Park,2 S. Ahn,1 J. Hwang,1 S. Kim,1 S. Park,1 S. Kim,1 J. Kim,1 I. Moon.1

1Vascular and Transplant Surgery, The Catholic University of Korea, Seoul, Korea
2Vascular Surgery, Inha University, Incheon, Korea.

Meeting: 2015 American Transplant Congress

Abstract number: A128

Keywords: Graft survival, Panel reactive antibodies

Session Information

Session Name: Poster Session A: Kidney Antibody Mediated Rejection

Session Type: Poster Session

Date: Saturday, May 2, 2015

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Exhibit Hall E

Purposes: This study was conducted to investigate the impact of pre-transplant PRA level on rejection and graft survival after kidney transplantation in patients with negative cross-match and no donor specific antibody(DSA).Methods and Materials: This is retrospectively 513 kidney recipients transplanted at our center from January 2009 to April 2013. And among them, those who identified positive test on cross-match, those who had donor specific antibodies, ABO incompatible, and those who had no information of PRA were excluded(n=130). The clinical characteristic was analyzed. Peak PRA was stratified into 3 groups according to their PRA levels group I, PRA=0; group II, PRA< 50%, and group III, PRA>50%. Results: Among 433 study population,347(80.1%) group I; 55(12.7%) group II ; 31(7.2%) group III. The rejection rate was 20.1% (group I 18.5% vs. group II 23.8% vs. group III 33.3% (p=.053)). The graft failure rate was 21.7%(group I 6.4% vs. group II 7.1% vs. group III 7.4% (p=.792)). Univariate analysis by log-rank test, donor source and rejection were significantly associated with graft survival(p=0.000 and 0.000, respectively). On multivariate Cox regression analysis, donor source and rejection were also significantly associated with graft survival(p<.05 and p<.05, respectively), however including subcatergories of PRA(p=.552).Conclusions: The rate of rejection showed strong trend to significant, as PRA group increases(p=.053). Pre-transplant PRA value was not significantly associated with graft survival, in patients with CXM(-) and DSA(-). However, donor source and presence of rejection were significantly associated with graft failure.

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To cite this abstract in AMA style:

Jun K, Kim M, Kim H, Park K, Ahn S, Hwang J, Kim S, Park S, Kim S, Kim J, Moon I. Impact of Pre-Transplant Panel Reactive Antibody Levels On Renal Graft Survival in Patients With Negative Cross-Match and No Donor Specific Antibody [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-pre-transplant-panel-reactive-antibody-levels-on-renal-graft-survival-in-patients-with-negative-cross-match-and-no-donor-specific-antibody/. Accessed May 8, 2025.

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