The aim of this study was to evaluate the distribution of UGT1A9 promoter region T-275A and C-2152T single nucleotide polymorphisms (SNPs) in stable transplant patients and to

investigate the impact of these SNPs on the evolution of this population after 10 years of follow up. Methods. In total, 873 caucasian renal transplant recipients were studied. The median time of follow up was 91.8 months (P25-75 46-146). It was performed an amplification with specific "primers" to delimit the study area for each polymorphism. Amplification was performed in a real-time PCR. Results. The T-275A promoter mutation was detected in 13% of patients and the C-2152T in 12%. Survival analysis was performed on 873 renal transplants patients carried out between 2004 and 2013. We found a higher frequency of death from cancer among carriers of polymorphism ( p. 001). We showed that carriers of T-275A and/or C-2152T had same incidence of acute graft rejection as non-carriers.

Conclusion. It seemed that carriers of T-275A and C-2152T SNPs of the UGT1A9 gene promoter region in our group, showed a greater incidence of death from cáncer. In particular they had a higher cumulative incidence of deaths from gastrointestinal tumors.

CITATION INFORMATION: Calvo N, Perez-Flores I, Shabaka A, Moreno M, Rodriguez-Cubillo B, Delgado J, Calvo M, Sanchez-Fructuoso A. Impact of Polymorphisms of UGT 1 A9 on the Prognosis of Renal Transplant Patients. Association with Digestive Tumors. Am J Transplant. 2017;17 (suppl 3).

« Back to 2017 American Transplant Congress