ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Impact of Non-Adherence in a Cohort of Kidney Transplant Recipients.

M. Merino-López,1 C. Flores-Gama.2

1National Autonomous University of Mexico, Mexico, Mexico
2Nephrology, National Institute of Cardiology, Mexico, Mexico

Meeting: 2017 American Transplant Congress

Abstract number: D276

Keywords: Graft failure, Graft survival, Kidney transplantation, Risk factors

Session Information

Session Name: Poster Session D: Long Term Kidney Outcomes

Session Type: Poster Session

Date: Tuesday, May 2, 2017

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Background: The understanding of the main causes of allograft losts and related factors is a critical in the sucess of kidney transplantation programs.

Objective: The aim of this study was to identify which are the factors associated to the allograft loss in a mexican cohort of kidney transplant recipients.

Methods: All consecutive adult kidney allograft recipients in an academic-hospital in Mexico City were included. Primary non-function allograft, recipients of two solid organs and deaths in the first 24 hours after sugery were excluded. Kidney allograft loss censured to death was defined as the permanent requirement of dialysis or a new allograft.

Results: We included 303 kidney transplant recipients between 2004 and 2015. The median of age was 26 years old (21-34), 55% male, 86.8% living-donors, 84.5% with unknow cause of CKD, 82% recieved an anti-IL-2 receptor antibodies as induction therapy and 85% maintenance with calcineurin inhibitor, mycophenolate and prednisone, the median of follow-up was 54 months (27-92). Thirty-six patients lost the graft, the main causes were unknown (37.4%), antibody mediated rejection (25.7%), mixed rejection (20%). The probability of survival beyond eleven years was superior in the adherent vs non-adherent group (91.3 % vs 18.3; p<0.001). Non adherence was associated with an increase of antibody mediated rejection (OR 5.6,[2.0-15.4]).Multivariable analysis showed that deceased donor (hazard ratio [HR], 2.61; 95% confidence interval 95% CI], 1.01-6.00, P=0.03), non adherence (HR, 2.5; 95% CI, 0.6-10.9; P=0.23) and non adherence x time (HR, 1.03; 95% CI, 1.0-1.06; P=0.03) increased the risk of allograft loss. Non adherent patients tend to be younger (23 years-old [20-31] vs (27 years-old, [21-34], p=0.06) and had less time on dialysis before transplant (14 months [10.5-30.5] vs 22 months [12-45), p=0.05] months than adherent patients.

Conclusions: The main cause of graft loss was rejection. Non adherence was the main risk factor for allograft loss, and the risk conferred by it increased with time.Younger patients with shorter time between ERC diagnosis and kidney transplant tend to be less adherent.

CITATION INFORMATION: Merino-López M, Flores-Gama C. Impact of Non-Adherence in a Cohort of Kidney Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Merino-López M, Flores-Gama C. Impact of Non-Adherence in a Cohort of Kidney Transplant Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-non-adherence-in-a-cohort-of-kidney-transplant-recipients/. Accessed May 9, 2025.

« Back to 2017 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences