Date: Sunday, June 2, 2019
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Abdominal aortic calcification (AAC) is known as a risk factor of cardiovascular diseases and renal dysfunction. We have reported that the significance of the recipient AAC strongly related with poor prognosis among living donor liver transplantation (LDLT). However, there are few data about the clinical implications of incidental donor AAC findings in LDLT. Therefore, we analyzed the impact of donor AAC on the prognosis and complications including bile duct complication (BC) following LDLT.
*Methods: A total of 154 consecutive patients who underwent LDLT from 2007 were divided into two groups according to their donor AAC level (< or ≥ 100 mm3), as calculated using the Agatston method. We evaluated the overall-survival and common complications including acute rejection, post-operative hemorrhage, blood-stream infection, cytomegalovirus infection, cardiovascular disease, and BC. We also evaluated the blood flow to the graft on postoperative day 1, using the doppler ultrasound examination.
*Results: The donor AAC level had a strong relation with donor age. High donor AAC was a risk factor for BC (56.3% vs 29.7%, p=0.03), but not for prognosis of recipients. There were no significant differences in other complications. Then, we analyzed the risk factors for BC. Multivariate analysis revealed that high donor AAC (Odds ratio; 3.62), absence of splenectomy (Odds ratio; 2.64), and right lobe graft (Odds ratio; 2.59) were the independent risk factors for BC after LDLT. The recipients from graft with high AAC donor had higher RI (resistance index) and lower EDV (end-diastolic velocity) in hepatic artery by ultrasound examination.
*Conclusions: A possible reason why high AAC donor graft had high rates of BC would be related with the blood supply of bile ducts which was supplied from arterial flow. The graft from high AAC donor could decrease the blood supply to the bile duct and cause the BC. In conclusion, high donor AAC was an independent prognostic factor of BC among LDLT.
To cite this abstract in AMA style:Imaoka Y, Ohira M, Sato K, Tahara H, Ide K, Tanaka Y, Ohdan H. Impact of Donor Abdominal Aortic Calcification on Bile Duct Complications of Recipients after Living Donor Liver Transplantation; a Retrospective Study [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-donor-abdominal-aortic-calcification-on-bile-duct-complications-of-recipients-after-living-donor-liver-transplantation-a-retrospective-study/. Accessed October 1, 2020.
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