ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Identifying Independent Risk Factors for Graft Loss After Primary Liver Transplantation: A Propensity Score Matched Analysis.

J. Gwiasda, H. Schrem, A. Kaltenborn.

Core Facility Quality Management Transplantation, Hannover Medical School, Hannover, Germany

Meeting: 2017 American Transplant Congress

Abstract number: B199

Keywords: Graft failure, Hepatic artery, Liver transplantation, Risk factors

Session Information

Session Name: Poster Session B: Liver Retransplantation and Other Complications

Session Type: Poster Session

Date: Sunday, April 30, 2017

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

This study aims to identify independent risk factors for graft loss after primary liver transplantation beyond the occurrence of hepatic artery thrombosis. Graft loss was defined as the necessity for re-transplantation or patient´s death due to graft loss. Analyzed were 834 adult patients undergoing primary liver transplantation at Hannover Medical School between 07.06.2002-31.12.2015. It is known that the onset of hepatic artery thrombosis is highly correlated with early graft loss as also shown in the current data. A propensity score was developed using multivariable binary logistic regression with hepatic artery thrombosis as the dependent variable. The logit link function of the propensity score was included into multivariable Cox regression analyses for graft loss to match the study population.Graft loss was observed in 129 patients (15.5%). Multivariable Cox regression analysis revealed recipient platelet count (p=0.01; HR: 1.002; 95%-CI: 1.000-1.003), a preoperative portal vein thrombosis (p=0.02; HR: 2.029; 95%-CI: 1.140-3.426), donor age (p=0.001; HR: 1.024; 95%-CI: 1.009-1.039), the percentage of macrovesicular steatosis in the donor graft (p=0.03; HR: 1.035; 95%-CI: 1.004-1.063), complications leading to surgical intervention after transplantation (p<0.001; HR: 3.572; 95%-CI: 2.372-5.467), the duration of the transplant procedure in minutes (p=0.002; HR: 1.004; 95%-CI: 1.002-1.007) as well as the transplantation of a split liver graft (p=0.004; HR: 2.613; 95%-CI: 1.364-4.841) to be independent risk factors for graft loss. The logit of the propensity score for the matching of the occurrence of hepatic artery thrombosis did not reach statistical significance in the final multivariable Cox regression model (p=0.25). In conclusion, liver transplant programs might benefit from regular donor organ biopsies. Pairing of an elderly donor with a recipient with a high platelet count or pre-transplant portal vein thrombosis should be avoided. This is especially the case when macrovesicular steatosis is observed or transplantation of a split graft is planned.

CITATION INFORMATION: Gwiasda J, Schrem H, Kaltenborn A. Identifying Independent Risk Factors for Graft Loss After Primary Liver Transplantation: A Propensity Score Matched Analysis. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Gwiasda J, Schrem H, Kaltenborn A. Identifying Independent Risk Factors for Graft Loss After Primary Liver Transplantation: A Propensity Score Matched Analysis. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/identifying-independent-risk-factors-for-graft-loss-after-primary-liver-transplantation-a-propensity-score-matched-analysis/. Accessed May 9, 2025.

« Back to 2017 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences