hTERT, BICD1 and Chromosome 18 Polymorphisms Affecting Telomere Length Are Associated With Kidney Transplantation Outcome
1Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland
2Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Szczecin, Poland
3Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Szczecin, Poland
4Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Meeting: 2015 American Transplant Congress
Abstract number: A45
Keywords: Gene polymorphism, Graft function, Kidney transplantation
Session Information
Session Name: Poster Session A: Delayed Function/Acute Injury/Outcomes/Glomerulonephritis
Session Type: Poster Session
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Telomere length (TL) has been analyzed in regard to cell senescence and ageing of animals and humans, including age-related diseases. There have been also attempts to link the accelerating transplanted organ ageing with TL and telomerase activity assessment. The aim of this study was to analyze the recipients' rs2735940 hTERT and rs2630578 BICD1 genes polymorphisms and rs7235755/rs2162440 chromosome 18 polymorphisms, which affect the telomere length and correlate them with kidney transplantation outcome.
The study enrolled 119 Polish Caucasian kidney allograft recipients (64M/55F, mean age 47.32±14.03; transplantation performed between 2001 and 2012). The genotypes of the studied polymorphisms were assessed with use of RT-PCR.
Creatinine concentrations 24 and 36 months after transplantation differed among the recipients' rs2630578 BICD1 gene polymorphism genotypes (p=0.009 and 0.02 respectively) and were higher among the C allele carriers (GG vs GC+CC p=0.008 and p=0.008 respectively). Differences in creatinine concentrations in regard to hTERT and BICD1 genes polymorphisms genotypes were not statistically significant.
Recipients' rs2630578 BICD1 gene polymorphism apart from association with TL affects kidney allograft transplantation outcome.
To cite this abstract in AMA style:
Domanski L, Kloda K, Safranow K, Drozd A, Ciechanowski K, Ciechanowicz A. hTERT, BICD1 and Chromosome 18 Polymorphisms Affecting Telomere Length Are Associated With Kidney Transplantation Outcome [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/htert-bicd1-and-chromosome-18-polymorphisms-affecting-telomere-length-are-associated-with-kidney-transplantation-outcome/. Accessed June 7, 2025.« Back to 2015 American Transplant Congress