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HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation

E. Kanimdan,1 B. Goncu,2 Y. Gelmez,3 O. Idiz,4 C. Toka,5 B. Ozdemir,2 H. Basoglu,6 N. Ozten Kandas,7 E. Yucesan,8 Y. Ersoy,5 R. Kazancioglu,9 E. Aysen.5

1Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
2Bezmialem Vakif University, Experimental Research Center, Istanbul, Turkey
3Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Immunology, Istanbul, Turkey
4Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey
5Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey
6Bezmialem Vakif University, Faculty of Medicine, Department of Biophysics, Istanbul, Turkey
7Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey
8Bezmialem Vakif University, Institute of Life Sciences and Biotechnology, Istanbul, Turkey
9Bezmialem Vakif University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey.

Meeting: 2018 American Transplant Congress

Abstract number: C10

Keywords: Donors, HLA matching, Major histocompatibility complex (MHC), unrelated

Session Information

Session Name: Poster Session C: Histocompatibility and Immunogenetics

Session Type: Poster Session

Date: Monday, June 4, 2018

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Permanent hypoparathyroidism(PH) is incurable condition and requires life long drug therapy.Unique therapeutic option is parathyroid allotransplantation(PA).Some studies use routinely but emprically HLA typing,PRA(panel reactive antibody) and DSA(donor specific antigen) screening tests before PA.In this research we aimed to evaluate the effectiveness of HLA,PRA and DSA for success of PA.We performed PA to unrelated four recipients from one living donor.HLA typing,PRA and DSA levels were observed.Recipients were discharged from the hospital without any complications and observed throughout four years.Two out of four PAs were successful.No correlations were observed for the success of transplantation about the tests of HLA typing,PRA and DSA(Table 1).In conclusion HLA typing,PRA and DSA tests were not necessary for PA.

Table 1. Comparision of pre-/post-transplant results. Rcp:Recipient

HLA-A HLA-B HLA-C HLA-DRB1 HLA-DQB1
Donor A*26 /A*32 B*14 /B*44 C*05 / C*08 B1*01 /B1*04 B1*03 / B1*05
Rcp 1 A*11 /A*24 B*44 /B*51 C*04 / C*07 B1*13 /B1*13 B1*06 / B1*06
Rcp 2 A*02 /A*68 B*18 / B*51 C*07 / C*15 B1*11 /B1*11 B1*03 / B1*03
Rcp 3 A*01 /A*32 B*08 / B*57 C*06 / C*07 B1*03 /B1*03 B1*02 / B1*02
Rcp 4 A*02 /A*02 B*51 / B*51 C*07 / C*15 B1*11 /B1*16 B1*03 / B1*05

CITATION INFORMATION: Kanimdan E., Goncu B., Gelmez Y., Idiz O., Toka C., Ozdemir B., Basoglu H., Ozten Kandas N., Yucesan E., Ersoy Y., Kazancioglu R., Aysen E. HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Kanimdan E, Goncu B, Gelmez Y, Idiz O, Toka C, Ozdemir B, Basoglu H, Kandas NOzten, Yucesan E, Ersoy Y, Kazancioglu R, Aysen E. HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation [abstract]. https://atcmeetingabstracts.com/abstract/hla-typing-panel-reactive-antibody-and-donor-specific-antigen-tests-are-not-necessary-for-successful-parathyroid-allotransplantation/. Accessed May 9, 2025.

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