Date: Sunday, June 12, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Purpose: Through several registries, it has been found that gender mismatch, female donor-to-male recipient (F/M) compared to male donor-to-male recipient (M/M) has lower survival. These findings may relate to the development of antibodies against H-Y antigens (from the male Y chromosome), size mismatch or force of contraction mismatch.
Methods: Between 1987 and 2013 we assessed 37,889 heart transplant patients in the UNOS database in regard to gender matching. Patients were divided into groups depending on recipient age: Group A (18-30 years), Group B (31-50 years) and Group C (>50 years) with 3 year survival calculated according to gender mismatch F/M vs M/M.
Results: F/M recipient gender mismatch had significantly lower 3-year survival compared to M/M for Group B and Group C. However, there was no significant difference in 3-year survival for both F/M and M/M donor-to-recipient groups aged 18-30 at the time of transplant.
Conclusions: Heart transplant patients with F/M recipient gender mismatch (compared to M/M) have significantly lower survival except in heart transplant patients ages 18-30. Gender mismatch does not appear to be a mortality risk in younger heart transplant patients. Further investigation into this observation is warranted.
|3-Year Actuarial Survival|
|Donor-Recipient Gender||F-M%||M-M%||Log Rank P-Value|
|Group A: Ages 18-30||N=2252||77.2%||79.9%||0.240|
|Group B: Ages 31-50||N=10946||80.1%||82.5%||0.007|
|Group C: Ages > 50||N=24691||76.5%||80.9%||<0.001|
CITATION INFORMATION: Kobashigawa J, Kittleson M, Czer L, Aintablian T, Passano E, Chang D, Esmailian F, Patel J. Gender Mismatch in the UNOS Heart Transplant Database: Not a Factor in Younger Heart Transplant Patients. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Kobashigawa J, Kittleson M, Czer L, Aintablian T, Passano E, Chang D, Esmailian F, Patel J. Gender Mismatch in the UNOS Heart Transplant Database: Not a Factor in Younger Heart Transplant Patients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/gender-mismatch-in-the-unos-heart-transplant-database-not-a-factor-in-younger-heart-transplant-patients/. Accessed April 10, 2020.
« Back to 2016 American Transplant Congress