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Favorable Outcomes in Older Recipients Receiving Simultaneous Kidney Pancreas Transplantation

P. Budhiraja1, H. Me1, J. Ninan2, S. Reddy2, s. S. Misra1, R. Heilman1, H. Khamash1, K. Reddy1, C. Jadloweic1, N. Katariya1, H. Chakkera1

1Mayo Clinic, Phoenix, AZ, 2Mayo Clinic, Rochester, MN

Meeting: 2022 American Transplant Congress

Abstract number: 1157

Keywords: Age factors, Graft survival, Kidney/pancreas transplantation, Outcome

Topic: Clinical Science » Pancreas » 65 - Pancreas and Islet: All Topics

Session Information

Session Name: Pancreas and Islet: All Topics

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: Improved therapeutic advances in diabetes mellitus care have resulted in a higher number of older diabetics on dialysis. The majority of centers use an age cut-off of 50 years for Simultaneous Kidney Pancreas transplantation (SKP) due to the concern for poor graft survival and complications. The objective of this study was to compare the long-term outcomes of older (>50 years and <50 years) diabetic patients who received SKP transplant.

*Methods: We retrospectively evaluated 317 SKP transplant recipients at our center from July 2003 to March 2021.

*Results: There were 101(32%) subjects above 50 years and 216 (68%) subjects aged < 50years who received SKP. Median(IQR) follow-up was 7 (3.9,11) years. Table 1 provides differences in recipient and donor characteristics. Mean age was 56.5 in >50 years and 39 in the younger cohort(p<0.001). Duration of diabetes was higher in the older cohort (31.6 vs. 25, p<0.001). Donor characteristics were similar between the 2 groups. Incidence of delayed graft function, length of stay, readmission were similar. Serum creatinine, Hba1c, and C-peptide post-transplant were comparable (Table 2). Incidence of acute rejection of kidney and pancreas by 1-year (including the for cause, protocol biopsy, and borderline rejection) were also similar(Table 2). Estimated 3-year death censored pancreas (83% vs. 87%) and kidney graft survival (94% vs. 96%) were similar between the two cohorts. Patient survival was lower as expected but acceptable at 3 years in the older group (92% vs. 96.5%). Death censored pancreas (log-rank 0.67) and kidney survival (log-rank 0.43) were similar between the 2 groups.

*Conclusions: Subjects older than 50 years have similar pancreas and kidney graft survival compared to the younger cohort receiving SKP transplants.

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To cite this abstract in AMA style:

Budhiraja P, Me H, Ninan J, Reddy S, Misra sS, Heilman R, Khamash H, Reddy K, Jadloweic C, Katariya N, Chakkera H. Favorable Outcomes in Older Recipients Receiving Simultaneous Kidney Pancreas Transplantation [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/favorable-outcomes-in-older-recipients-receiving-simultaneous-kidney-pancreas-transplantation/. Accessed May 9, 2025.

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