ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Efficacy and Safety According to Dose of Valganciclovir for Cytomegalovirus Prophylaxis in Transplantation Network Meta Analysis

S. Hwang, W. Park, K. Kim, J. Song, S. Lee

Inha University, Incheon, Korea, Republic of

Meeting: 2020 American Transplant Congress

Abstract number: A-200

Keywords: Cytomeglovirus, Efficacy, Infection, Prophylaxis

Session Information

Session Name: Poster Session A: Kidney Infectious Excluding Polyoma & Viral Hepatitis

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Valgancivlovir is importantly used to prevent post-transplant CMV infection among kidney transplantation patients. However, the dose of such drug being used still remains controversial since the continuous use of such drug decrease kidney functions and induces leukopenia in some of the cases. Accordingly, the purpose is to measure the appropriate dose of the drug required for preventing CMV using network Meta analysis.

*Methods: We searched the Cochrane Central Register, OVID MEDLINE and Pubmed until April 15, 2019. Studies evaluating among valganciclovir 900 mg, 450 mg and controls were evaluated. We performed direct and indirect network meta-analysis using Bayesian models and generated rankings of the different dose of valgaciclovir agents by generation mixed treatment comparison (GeMTC).

*Results: Twenty-three studies involving 3,478 participants were eligible. As a result of analyzing among three groups. Compared with control, there was no difference between low dose 0.79 [95% Crl, 0.50-1.40] and standard dose 1.0 [95% Crl, 0.61-1.60] groups when CMV incidence was compared. In the Rank probabilities table, the best order for lowering the CMV event was as high as dose of 450mg (71.1%). Incidence of leukopenia showed a significant difference, but there was no statistical significance in the low dose group 1.5 [95% Crl, 0.99-2.20] compared with the control group, but 4.3 times higher in the high dose group [95% Crl, 2.69-7.10 ], which was 2.9 times higher in the high dose group compare with low dose group [95% Crl, 1.88 -4.67].

*Conclusions: The use of valganciclovir did not show any difference in other side effects, but the use of low doses of leukopenia significantly reduced side effects. The incidence of CMV was not different among the three groups, but the tendency was also decreased at low dose.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Hwang S, Park W, Kim K, Song J, Lee S. Efficacy and Safety According to Dose of Valganciclovir for Cytomegalovirus Prophylaxis in Transplantation Network Meta Analysis [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/efficacy-and-safety-according-to-dose-of-valganciclovir-for-cytomegalovirus-prophylaxis-in-transplantation-network-meta-analysis/. Accessed June 6, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences