Effect of AKI Donor Admit Creatinine on Renal Transplant Outcomes.
1Department of Surgery, Mayo Clinic, Phoenix, AZ
2Department of Medicine, Mayo Clinic, Phoenix, AZ
3Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ
Meeting: 2017 American Transplant Congress
Abstract number: D265
Keywords: Donors, Graft survival, Kidney transplantation, marginal
Session Information
Session Name: Poster Session D: Long Term Kidney Outcomes
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Purpose of the study was to explore the effect of admit AKI donor creatinine on graft outcomes.
Method: Single center retrospective analysis of kidney transplants performed using organs from deceased AKI donors (terminal creatinine ≥ 2 mg/dl). Combined organ transplants were excluded. AKI kidneys with cortical necrosis or moderate/severe chronic changes were discarded. The cohort was divided based on admit donor creatinine (< or ≥ 1.5 mg/dl). Outcomes were graft survival, DGF, 1-, 4-month and 1-year creatinine/eGFR and Banff staging.
Results: 387 patients were included. 171 recipients had a donor admit creatinine ≥ 1.5 mg/dl (group 1), while the rest (group-2) a creatinine < 1.5 mg/dl. Group-1 donors were younger, female, with lower KDPI, non-hypertensive, oliguric and with higher terminal and peak creatinine levels.
| Group-1 | Group-2 | p | |
| Donor | |||
| Age (yrs) | 33.5±11.8 | 41.6±14.7 | <.0001 |
| Female | 19.3 | 39.4 | <.0001 |
| KDPI | 43.6±22.3 | 58.6±23.0 | <.0001 |
| HTN | 18.7 | 32.4 | 0.0024 |
| Oliguric | 60.0 | 36.8 | <.0001 |
| Peak creat. (mg/dl) | 6.38±2.91 | 4.15±1.99 | <.0001 |
| Term. creat. | 5.56±2.91 | 3.94±1.94 | <.0001 |
| Recipient | |||
| Age | 54.6±12.7 | 57.8±12.7 | 0.0142 |
Group-1 recipients were younger, with higher 1-week creatinine which became lower 4 months post-transplant. 1-year eGFR (CKD EPI formula) was better in group-1.
| Group-1 | Group-2 | p | |
| 4-month creat. (mg/dl) | 1.35±0.47 | 1.58±0.82 | 0.0012 |
| 4-month eGFR (ml/min/1.73m2) | 60.3±20 | 52.0±20.8 | 0.0002 |
| 1-yr eGFR | 62.1 ±21.6 | 55.5±21.0 | 0.0137 |
Graft survival was similar. 
Conclusion: For carefully selected AKI kidney donors, an elevated admit donor creatinine is not associated with inferior outcomes and these kidneys should be transplanted.
CITATION INFORMATION: Giorgakis E, Heilman R, Khamash H, Kaplan B, Moss A, Smith M, Reddy K. Effect of AKI Donor Admit Creatinine on Renal Transplant Outcomes. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Giorgakis E, Heilman R, Khamash H, Kaplan B, Moss A, Smith M, Reddy K. Effect of AKI Donor Admit Creatinine on Renal Transplant Outcomes. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/effect-of-aki-donor-admit-creatinine-on-renal-transplant-outcomes/. Accessed November 21, 2024.« Back to 2017 American Transplant Congress