Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Aim: It is not certain whether hyperuricemia is a true risk factor of kidney allograft failure. We investigated the association of hyperuricemia and graft outcome.
Methods: We performed a retrospective, multi-center cohort study including 2440 kidney transplant recipients. Patients were classified into the normouricemic or hyperuricemic group according to their level of serum uric acid (SUA) at post-transplant 3 month. Hyperuricemia was defined as a SUA level of[thinsp]≥[thinsp]7.0 mg/dL in male and[thinsp]≥[thinsp]6.0 mg/dL in female or when hypouricemic medications were prescribed. The effect of hyperuricemia on graft outcome, cardiovascular events, and recipient mortality were analyzed.
Results: 661 (27.1%) recipients were classified as the hyperuricemic group, among which 115 were prescribed urate lowering agents. There were 208 cases of graft failure, 44 cases of post-transplant cardiovascular events, and 84 cases of patient death during a median follow-up period of 71.0 months. Hyperuricemia was significantly associated with graft failure in multiple Cox regression analysis (Hazard ratio (HR) 1.383, 95% confidence interval [CI] 1.010 – 1.894, P=0.043). Major adverse cardiac events (HR 0.965, 95% CI 0.412-2.262, P=0.935) and recipient survival (HR 0.891, 95% CI 0.504-1.574, P=0.691) were not associated with hyperuricemia.
Conclusion: Hyperuricemia at post-transplant 3 month is associated with graft outcome. The patients showing early onset hyperuricemia after kidney transplant should be carefully monitored.
CITATION INFORMATION: Han M, Yang S, Jung I, Park S.-K, Kim Y, Han D, Kim Y, Kim S, Lee J. Early Onset Hyperuricemia Is a Prognostic Marker for Kidney Allograft Dysfunction. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Han M, Yang S, Jung I, Park S-K, Kim Y, Han D, Kim Y, Kim S, Lee J. Early Onset Hyperuricemia Is a Prognostic Marker for Kidney Allograft Dysfunction. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/early-onset-hyperuricemia-is-a-prognostic-marker-for-kidney-allograft-dysfunction/. Accessed March 5, 2021.
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