Early Onset Hyperuricemia Is a Prognostic Marker for Kidney Allograft Dysfunction.
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
2Kidney Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
3Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Republic of Korea
4Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea
5Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea
6Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
7Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Meeting: 2016 American Transplant Congress
Abstract number: A239
Keywords: Graft failure, Kidney transplantation
Session Information
Session Name: Poster Session A: Long Term Outcomes in Kidney Transplantation
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Aim: It is not certain whether hyperuricemia is a true risk factor of kidney allograft failure. We investigated the association of hyperuricemia and graft outcome.
Methods: We performed a retrospective, multi-center cohort study including 2440 kidney transplant recipients. Patients were classified into the normouricemic or hyperuricemic group according to their level of serum uric acid (SUA) at post-transplant 3 month. Hyperuricemia was defined as a SUA level of[thinsp]≥[thinsp]7.0 mg/dL in male and[thinsp]≥[thinsp]6.0 mg/dL in female or when hypouricemic medications were prescribed. The effect of hyperuricemia on graft outcome, cardiovascular events, and recipient mortality were analyzed.
Results: 661 (27.1%) recipients were classified as the hyperuricemic group, among which 115 were prescribed urate lowering agents. There were 208 cases of graft failure, 44 cases of post-transplant cardiovascular events, and 84 cases of patient death during a median follow-up period of 71.0 months. Hyperuricemia was significantly associated with graft failure in multiple Cox regression analysis (Hazard ratio (HR) 1.383, 95% confidence interval [CI] 1.010 – 1.894, P=0.043). Major adverse cardiac events (HR 0.965, 95% CI 0.412-2.262, P=0.935) and recipient survival (HR 0.891, 95% CI 0.504-1.574, P=0.691) were not associated with hyperuricemia.
Conclusion: Hyperuricemia at post-transplant 3 month is associated with graft outcome. The patients showing early onset hyperuricemia after kidney transplant should be carefully monitored.
CITATION INFORMATION: Han M, Yang S, Jung I, Park S.-K, Kim Y, Han D, Kim Y, Kim S, Lee J. Early Onset Hyperuricemia Is a Prognostic Marker for Kidney Allograft Dysfunction. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Han M, Yang S, Jung I, Park S-K, Kim Y, Han D, Kim Y, Kim S, Lee J. Early Onset Hyperuricemia Is a Prognostic Marker for Kidney Allograft Dysfunction. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/early-onset-hyperuricemia-is-a-prognostic-marker-for-kidney-allograft-dysfunction/. Accessed May 9, 2025.« Back to 2016 American Transplant Congress