Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: Biolasol is a newly developed preserving solution for cold organ storage prior to transplantation. The aim of this study was to compare in the clinical settings the early post-transplant course of kidney grafts preserved with Biolasol in comparison with traditional used preservation solutions.
*Methods: One-hundred-seventy-three organs were preserved before transplantation using Biolasol and 173 organs were preserved with traditionally used solutions (UW, IGL or Store Protect). Early graft function was defined based on serum creatinine concentration at 3rd day (<3 mg/dl - immediate graft function, IGF or >3 mg/dl – slow graft function, SGF) or the need of dialysis therapy during first postoperative week (delayed graft function, DGF). The analysis included intrarenal resistive indices measured by Doppler sonography few days after transplantation and before discharge from the hospital.
*Results: IGF was more frequent in patients with organs preserved with traditional solutions (28.3 vs. 18.5%, p=0.03), whereas there was no difference in the occurrence of DGF. Both initial and discharge median resistance index values were significantly higher in the Biolasol group (0.77 vs. 0.70 and 0.75 vs. 0.69, respectively, both p<0.001). Median serum creatinine concentrations were higher in the Biolasol group (post-transplant day 3: 524 vs. 476, p<0.05, day 7: 270 vs. 206, p<0.05 and at discharge: 147 vs. 130 µmol/l, p<0.01). Multiple logistic regression analysis revealed that ECD status [OR 0.28 (95%CI: 0.14-0.56)], CIT >18 h [OR 0.52 (0.32-0.83) and the use of Biolasol solution [OR 0.47 (0.29-0.75)] were independently decreasing the occurrence of IGF.
*Conclusions: In this first clinical application in a large cohort of kidney transplanted patients, kidney preservation using Biolasol solution was associated with significantly worse early graft function and higher intrarenal resistant index in comparison with traditional preservation fluids. Long term follow-up is needed in order to assess the kidney graft and patient survival.
To cite this abstract in AMA style:Kolonko A, Król R, Chudek J, Cierpka L, Więcek A. Early Graft Function and Intrarenal Resistant Index after Kidney Transplantation Using New Preservation Fluid (Biolasol) [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/early-graft-function-and-intrarenal-resistant-index-after-kidney-transplantation-using-new-preservation-fluid-biolasol/. Accessed December 4, 2020.
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