Date: Monday, June 13, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Donor age is a determinant of allograft outcome after deceased donor kidney transplant (DDTx). Our aim was to determine if chronic changes on a reperfusion biopsy (Bx), after adjusting for donor age, provides any additional risk for a lower eGFR after DDTx.
All patients who received a DDTx between July 2003 and April 2015 were included if they had eGFR available 1 year post transplant. The primary outcome was eGFR by CKD-EPI at 1 year post DDTx. We used a logistic regression analysis to determine the interaction between donor age and Banff ci>0 and ct>0 on reperfusion Bx with the eGFR at 1 year. Continuous data shown as mean±SD.
1054 patients received a DDTx during the study period. 708 (67.2%) had eGFR measurement available at 1 year. The eGFR for the entire group was 58.9±20.9 and 126 (17.8%) had eGFR < 40. A Bx was available in 79 (62.7%) of the low GFR group and 389 (66.8%) in the higher GFR group. Baseline characteristics are shown in table 1.
|eGFR<40(n=126)||eGFR≥40 (n=582)||P value|
|Recipient race Black||11.9%||8.4%||0.23|
|Donor terminal creatinine||1.62±2.50||1.70±1.84||0.68|
On the univariate analysis, donor age, Bx ci>0 and Bx ct>0 were all associated with a significant higher risk of low eGFR at 1 year (table 2), however, after controlling for donor age, the Bx ci>0 and ct>0 were no longer significant.
|RR||95% CI||P value||RR||95% CI||P value|
|Donor age (per year)||1.05||1.04-1.07||<.0001||1.05||1.03-1.07||<.0001|
We also compared the eGFR for the group with donor age ≥ 60 stratified by the Bx ci score (ci=0 vs ci>0) and the eGFR at 1 year was the same (44.1±18.4 vs 44.7±15.1, p=0.88). There were no differences in rejection or BK infection between the groups.
After adjusting for donor age, donor derived interstitial fibrosis and tubular atrophy is not independently associated with a lower GFR at 1 year.
CITATION INFORMATION: Heilman R, Qaqish I, Smith M, Khamash H, Kaplan B, Reddy K. Donor Interstitial Fibrosis and Tubular Atrophy (IFTA) Are Not Independent Risk Factors for a Lower GFR at One Year. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Heilman R, Qaqish I, Smith M, Khamash H, Kaplan B, Reddy K. Donor Interstitial Fibrosis and Tubular Atrophy (IFTA) Are Not Independent Risk Factors for a Lower GFR at One Year. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/donor-interstitial-fibrosis-and-tubular-atrophy-ifta-are-not-independent-risk-factors-for-a-lower-gfr-at-one-year/. Accessed November 29, 2020.
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