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Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation

T. Ueno,1,2,3 M. Yeung,1 M. McGrath,1 H. Iwamoto,3 Y. Nakamura,3 O. Konnno,3 Y. Kihara,3 T. Yokoyama,3 S. Ono,3 T. Ikeda,3 S. Kawachi,3 B. Ibrahim,1 A. Chandraker.1

1Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
2Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
3Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.

Meeting: 2015 American Transplant Congress

Abstract number: C20

Keywords: Antigen presentation, Heart, Image analysis, Mice

Session Information

Session Name: Poster Session C: Antigen Presenting Cells in Alloimmune Responses/B Cells and Antibody in Alloimmune Responses

Session Type: Poster Session

Date: Monday, May 4, 2015

Session Time: 5:30pm-6:30pm

 Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most potent antigen-presenting cells and have proven to be major regulators in determining the fate of the alloimmune response. By monitoring the complex behavior of cells, it will possible to answer many of outstanding questions in the field.

Methods:

We have now adapted the use of intravital microscopy (IVM) to track EYFP DC motility, morphology, and cell density in real-time.

Results:

Since dDC located at graft are exposed to host cells right after reperfusion, our recent findings could provide us the following possibilities; 1) dDC have already been activated during ischemic time to prepare for start cross-talking with host cells right after reperfusion, and 2) dDC are the most potent antigen presenting cells, which suggest “dDC might play an emerging role as a bridge between innate immunity and alloimmunity in cardiac transplant model”.

Conclusions:

To our knowledge, this is the first observation that T cells can be primed by interactions with dDC outside of secondary lymphoid tissues following transplantation within an hour. If this is the case, dDC could be the most potent therapeutic target in cardiac transplant model.

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To cite this abstract in AMA style:

Ueno T, Yeung M, McGrath M, Iwamoto H, Nakamura Y, Konnno O, Kihara Y, Yokoyama T, Ono S, Ikeda T, Kawachi S, Ibrahim B, Chandraker A. Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/donor-dendritic-cells-potential-new-therapeutic-target-in-transplantation/. Accessed May 31, 2025.

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