Date: Monday, May 1, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
The relationship between DCD LT and post-LT renal dysfunction is unclear. Aim: Determine the effects of DCD LT compared to donation after brain death (DBD) LT on post-LT renal outcomes including 1) renal function at 1, 4 and 12 month; 2) new onset acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the 1st post-LT month and 3) end-stage renal disease (ESRD) at 1 year from LT. Methods: Data on 1325 (1157 DBD and 168 DCD) 1ry LT performed between January 2003 and December 2011 were retrospectively reviewed. Kidney function was assessed by serum creatinine (Cr) at 1, 4 and 12 months post-LT and 24-hr urine Cr clearance at 1 year. Rates of AKI requiring RRT within the 1st post-LT month and ESRD at 1 yr were recorded. Patient and graft survival were calculated using the Kaplan-Meier method and compared between DBD and DCD LT. Results: Patients' demographics and post-LT renal outcomes are summarized in Table 1.
|DBD (n=1157)||DCD (n=168)||P|
|Age||56±10||55.5 ± 9.6||0.8|
|Serum Cr at LT||1.1±0.7||1.0±0.6||0.2|
|Pre-LT 24-hr Cr clearance||72±37||74±38||0.7|
|%on RRT at LT||5.7||6||0.9|
|%New AKI post-LT||5.4||4.8||0.7|
|%ESRD at 1 yr||2.7||4.2||0.3|
|1 month Cr||1.2±0.5 n=1124||1.2±0.5 n=161||0.9|
|4 month Cr||1.3±0.6 n=1008||1.2±0.4 n=149||0.4|
|1 yr Cr||1.2±0.5 n=873||1.2±0.4 n=133||0.3|
|1 yr 24 hr Cr clearance||61±25 n=722||63±27 n=113||0.4|
Patient and graft survivals were also similar between DBD and DCD LT (Figure 1). Conclusions: 1)DCD LT is not associated with increased risk of post-LT AKI requiring RRT within the 1st month post-LT or ESRD within the 1st year post-LT. 2)Serum Cr and Cr clearance were similar at 1, 4 and 12 months post-LT between DCD and DBD LT recipients.
CITATION INFORMATION: Wadei H, Mai M, Lee D, Croome K, Rosser B, Keaveny A, Taner B. Donation After Cardiac Death (DCD) Liver Transplantation (LT) Is Not Associated with Post-LT Renal Dysfunction. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Wadei H, Mai M, Lee D, Croome K, Rosser B, Keaveny A, Taner B. Donation After Cardiac Death (DCD) Liver Transplantation (LT) Is Not Associated with Post-LT Renal Dysfunction. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/donation-after-cardiac-death-dcd-liver-transplantation-lt-is-not-associated-with-post-lt-renal-dysfunction/. Accessed August 15, 2020.
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