Donation After Cardiac Death (DCD) Liver Transplantation (LT) Is Not Associated with Post-LT Renal Dysfunction.

H. Wadei, M. Mai, D. Lee, K. Croome, B. Rosser, A. Keaveny, B. Taner.

Transplant, Mayo Clinic, Jacksonville, FL

Meeting: 2017 American Transplant Congress

Abstract number: C189

Keywords: Donors, Liver transplantation, non-heart-beating, Renal function

Session Information

Session Name: Poster Session C: Organ Allocation, Meld Score, Organ Utilization, and Transplant Outcomes

Session Type: Poster Session

Date: Monday, May 1, 2017

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall D1

The relationship between DCD LT and post-LT renal dysfunction is unclear. Aim: Determine the effects of DCD LT compared to donation after brain death (DBD) LT on post-LT renal outcomes including 1) renal function at 1, 4 and 12 month; 2) new onset acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the 1^st post-LT month and 3) end-stage renal disease (ESRD) at 1 year from LT. Methods: Data on 1325 (1157 DBD and 168 DCD) 1^ry LT performed between January 2003 and December 2011 were retrospectively reviewed. Kidney function was assessed by serum creatinine (Cr) at 1, 4 and 12 months post-LT and 24-hr urine Cr clearance at 1 year. Rates of AKI requiring RRT within the 1^st post-LT month and ESRD at 1 yr were recorded. Patient and graft survival were calculated using the Kaplan-Meier method and compared between DBD and DCD LT. Results: Patients' demographics and post-LT renal outcomes are summarized in Table 1.

	DBD (n=1157)	DCD (n=168)	P
Age	56±10	55.5 ± 9.6	0.8
% Male	67	73	0.1
% Caucasian	91	94	0.7
%HCV	38	49	0.005
MELD score	19±8	18±7	0.1
Serum Cr at LT	1.1±0.7	1.0±0.6	0.2
Pre-LT 24-hr Cr clearance	72±37	74±38	0.7
%on RRT at LT	5.7	6	0.9
Renal Outcomes
%New AKI post-LT	5.4	4.8	0.7
%ESRD at 1 yr	2.7	4.2	0.3
1 month Cr	1.2±0.5 n=1124	1.2±0.5 n=161	0.9
4 month Cr	1.3±0.6 n=1008	1.2±0.4 n=149	0.4
1 yr Cr	1.2±0.5 n=873	1.2±0.4 n=133	0.3
1 yr 24 hr Cr clearance	61±25 n=722	63±27 n=113	0.4

Patient and graft survivals were also similar between DBD and DCD LT (Figure 1). Conclusions: 1)DCD LT is not associated with increased risk of post-LT AKI requiring RRT within the 1^st month post-LT or ESRD within the 1^st year post-LT. 2)Serum Cr and Cr clearance were similar at 1, 4 and 12 months post-LT between DCD and DBD LT recipients.

CITATION INFORMATION: Wadei H, Mai M, Lee D, Croome K, Rosser B, Keaveny A, Taner B. Donation After Cardiac Death (DCD) Liver Transplantation (LT) Is Not Associated with Post-LT Renal Dysfunction. Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Wadei H, Mai M, Lee D, Croome K, Rosser B, Keaveny A, Taner B. Donation After Cardiac Death (DCD) Liver Transplantation (LT) Is Not Associated with Post-LT Renal Dysfunction. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/donation-after-cardiac-death-dcd-liver-transplantation-lt-is-not-associated-with-post-lt-renal-dysfunction/. Accessed November 22, 2024.

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