Background: Post-TACE pancreatitis in HCC patients is well documented complications. We sought to determine if prior h/o TACE in addition to other risk factors(RF) contributes to development of early post-op pancreatitis after LT in modern era and how early pancreatitis impacts LT outcomes.

Methods: We reviewed 134 adult recipients of primary DDLTx(2012-2014). Definitions: chemical pancreatitis (ChP)=elevated levels amylase/lipase (2Xnormal upper limit), clinical pancreatitis (CP)=ChP+symptoms and CT findings consistent with pancreatitis. Demographics, h/o TACE and additional pancreatitis RF were assessed by univariate analysis(UVA); those significant were studied using multivariate analysis(MVA). One-year rejection/mortality/graft failure and length of stay(LOS) were compared between the groups.

Results:

Incidence of early post-op CP was 4%(n=5), ChP 14%(n=19), diagnosed within one week of LT. H/o TACE, HCC and native portal vein thrombosis(PVT) were significant RF for development of CP and ChP in UVA. Native PVT and post-transplant venous/arterial thrombosis were independent RF for development of CP+ChP in MVA. In multivariate adjusted model, hospital/ICU LOS were significantly longer for CP as compared to ChP and no pancreatitis groups; there was no difference in 1-year rejection/mortality/graft failure.

Conclusions:

TACE, HCC and pre-op PVT were significant RF in development of early pancreatitis in UVA. In MVA, h/o TACE lost significance possibly due to small numbers; pre-op PVT and post-op venous/arterial thrombosis remained independent RF. Early CP after LT increased hospital/ICU LOS, but didn't increase 1-year rejection/mortality/graft failure rates in modern era.

CITATION INFORMATION: Kirchner V, Zhang L, Dunn T, Finger E, Hassan M, Kandaswamy R, Lake J, Liu P, Minja E, Serrano O, Pugalenthi A, Thompson J, Yadav K, Payne W, Pruett T, Chinnakotla S. Does Pre-Operative Transarterial Chemoembolization(TACE) Increase the Risk of Early Post-Operative Pancreatitis After Liver Transplantation(LT)? Am J Transplant. 2016;16 (suppl 3).

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