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Does HLA Class of Complement Activating Donor Specific Antibodies Matter: Single Centre Retrospective Analysis of Renal Allograft Outcomes.

A. Babu,1,2,3 D. Briggs,3 D. Mitchell,1 N. Krishnan,2 R. Higgins,1 S. Daga.1,2,4

1Warwick Medical School, University of Warwick, Coventry, United Kingdom
2Nephrology and Transplantation, University Hospitals Coventrya and Warwickshire, Coventry, United Kingdom
3Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom
4Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

Meeting: 2017 American Transplant Congress

Abstract number: B85

Keywords: Alloantibodies, Allorecognition, Graft survival, Highly-sensitized

Session Information

Session Name: Poster Session B: Antibody Mediated Rejection in Kidney Transplant Recipients II

Session Type: Poster Session

Date: Sunday, April 30, 2017

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Introduction. Complement activating donor specific antibodies may be associated with worse outcomes in a cohort of patients who have undergone HLA-AIT. We looked for differences in renal allograft outcomes in patients with HLA class 1 and class 2 complement activating IgG antibodies.

Methods: We analysed samples from 121 HLA-AIT who had pre-transplant DSA and subsequently underwent direct transplantation.C3d (Immucor) assay was performed at preconditioning/pre-transplant. IgG C3d results were correlated with HLA class and for prediction of rejection and allograft survival.

Results: Of 121 patients,11 had C3d positive IgG DSA for class1 and 31 had C3d positive IgG DSA positive for class 2. 5 patients had C3d IgG DSA positive for both classes. Either class 1 or class 2 C3d positive DSA was not associated with early rejection (p 0..64 and p0.146 respectively). C3d class 1 DSA was not associated with predicting long term graft survival (p 0.1) but class 2 DSA was associated with predicting long term outcome (p 0.001). Discussion: In this cohort of HLA-AIT renal transplants complement activating IgG donor specific antibodies directed against HLA class 2 antigens were associated with worse long term graft survival. This finding need to verified in larger sample and need to include de-novo antibodies.

CITATION INFORMATION: Babu A, Briggs D, Mitchell D, Krishnan N, Higgins R, Daga S. Does HLA Class of Complement Activating Donor Specific Antibodies Matter: Single Centre Retrospective Analysis of Renal Allograft Outcomes. Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Babu A, Briggs D, Mitchell D, Krishnan N, Higgins R, Daga S. Does HLA Class of Complement Activating Donor Specific Antibodies Matter: Single Centre Retrospective Analysis of Renal Allograft Outcomes. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/does-hla-class-of-complement-activating-donor-specific-antibodies-matter-single-centre-retrospective-analysis-of-renal-allograft-outcomes/. Accessed May 13, 2025.

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