Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)
1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH
European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research
German Center for Infection Research, TTU-IICH Hannover
Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Hannover
Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hannover
Hôpital Necker-Enfants Malades, Paris, France, 7Hannover
Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Children's Hospital, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Ospedali Riuniti di Bergamo, Bergamo, Italy, 11Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 12German Center for Infection Research, TTU-IICH Hannover
MHH
Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, 13Birmingham Children’s Hospital, UK
Division of Pediatric Gastroenterology and Hepatology, MHH, Hannover, Germany, 14Institute of Transplant Immunology, MHH
German Center for Infection Research, TTU-IICH, Hannover, Germany
Meeting: 2022 American Transplant Congress
Abstract number: 1454
Keywords: Immunogenicity, Immunosuppression, Liver transplantation, Risk factors
Topic: Clinical Science » Liver » 61 - Liver: Pediatrics
Session Information
Session Time: 7:00pm-8:00pm
Presentation Time: 7:00pm-8:00pm
Location: Hynes Halls C & D
*Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.
*Methods: Absolute cell counts and relative ratios of major immune populations in patient blood at visits: before (V0), 1 (V1), 2 (V2), 3 (V3), 4 (V4) wks, 3 (V5), 6 (V6) months and 1 year after pLTx (n>153) were quantified.
*Results: The majority of immune subsets decrease with increasing age. The top 15 altered immune parameters i.e. absolute counts and ratios of blood immune cells over pLTx separated at early V0-4 and at later visits V5-7. Absolute counts and ratio of granulocytes and monocytes peaked at V1, followed by their gradual decrease. In the same time CD3+ T cells, both CD4+ and CD8+ T cell subsets, and CD56+ NK cells reduce in numbers at V1 but recover by V3 with a further increase by V4-7. Specifically, the ratios of cytotoxic CD8+T and CD56dim NK cell subsets increase over V1-7, while regulatory CD4+T and CD56bri NK cells decrease. In addition, we identified cellular immune signatures linked to reduced inflammation and improved liver parameters.
*Conclusions: We describe here an interplay between myeloid and lymphocyte immune cells during one year after pLTx pointing towards potential immune targets for improved therapy.
To cite this abstract in AMA style:
Chichelnitskiy E, Ruhl L, Goldschmidt I, Karch A, Antiga L, Debray D, Hierro L, Kelly D, McLin V, Nicastro E, Pawlowska J, Czubkowski P, Mikolajczyk R, Baumann U, Falk C. Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx) [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/defining-the-longitudinal-dynamics-of-immune-cells-in-blood-in-the-first-year-after-pediatric-liver-transplantation-pltx/. Accessed May 9, 2025.« Back to 2022 American Transplant Congress