Introduction

De novo malignancies are one of the leading causes of late mortality after liver transplantation (LT). We analyze the clinical characteristics, prevalence, risk factors, prevention and treatment of de novo malignancies after LT.

Method

We analyzed de novo malignancies in patients who underwent LT at Seoul St.Mary's Hospital from June 1993 to September 2016.

Results

Twenty cases of de novo malignancies after LT occurred for an incidence rate of 2.4% (20/818). The distribution of tumor types included colon cancer, bladder cancer, pancreas cancer, lymphoma, lung cancer, renal cell cancer, gastric cancer, prostate cancer, primary peritoneal caner, esophageal cancer, cholangiocarcinoma, and hypophryngeal cancer. The incidence of de novo malignancies was 5.8% (2/291) in 5 to 10 years after LT, 2.96% (5/169) in 10 to 15 years and 8.51% (4/47) in 15 to 20 years, respectively. The standardized incidence ratio was 1.16, which was lower than that of western contries. The risk factors of de novo malignancies were identified as duration of immune suppression and cigarette smoking. (p<0.001) The surveillance program after LT allowed long term survival even with de novo malignancies.

Conclusions

De novo malignancies after LT has become a major source of morbidity and mortality. A close surveillance program for the diagnosis of malignancies could be life-saving in LT recipients.

CITATION INFORMATION: Yoon Y., Lee J., You Y., Kim D. De Nove Malignancies after Liver Transplantation: Single Center Experience in Korea Am J Transplant. 2017;17 (suppl 3).

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