ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Comparing Weight-Based Dosing of Envarsus XR in Obese and Non-Obese Renal Transplant Recipients

N. Breslin, N. Jandovitz, V. Nair, M. Abate, L. Teperman

North Shore University Hospital, Manhasset, NY

Meeting: 2020 American Transplant Congress

Abstract number: 608

Keywords: Calcineurin, Dosage, Kidney transplantation, Obesity

Session Information

Session Name: All Organs: Pharmacogenomics / Pharmacokinetics

Session Type: Oral Abstract Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:45pm

 Presentation Time: 4:15pm-4:27pm

Location: Virtual

*Purpose: Tacrolimus has a narrow therapeutic window and significant inter- and intra-patient variability leading to variations in drug concentration. The recommended initial weight-based dose of extended-release tacrolimus (LCPT; Envarsus XR) in kidney transplant recipients is 0.14 mg/kg/day. However, no data exist regarding weight-based LCPT dosing for obese patients. With significant differences between ideal body weight (IBW), adjusted body weight (ABW) and total body weight (TBW) in obese patients, doses may vary greatly based on the weight chosen, thereby affecting therapeutic concentrations.

*Methods: Single-center retrospective chart review of kidney transplant recipients initiated on de novo LCPT from July 1 to November 1, 2019. Multi-organ recipients, re-transplants on tacrolimus and patients with a gastric sleeve were excluded. The primary outcome was weight-based dosing requirements (mg/kg/day) to reach a therapeutic concentration (8-12 ng/mL) for obese kidney transplant recipients compared to non-obese recipients. Secondary outcomes include time to therapeutic concentrations and characterizing the optimal weight-based approach for dosing LCPT.

*Results: Of the 31 kidney transplant recipients, 13 (42%) were obese. Baseline characteristics were similar between both cohorts. The mean therapeutic dose was 0.13 mg/kg vs. 0.14 mg/kg in the obese and control groups based on IBW, respectively, (p=0.839). This finding was supported by a strong linear relationship between IBW and therapeutic dose (r = 0.94, p<0.001) vs. r=0.84 for TBW (Figure 1). In a multivariate analysis, age, sex, race, BMI, induction agent and delayed graft function did not influence therapeutic dose. Mean time to therapeutic concentration was 4 ± 1.75 days in both cohorts.

*Conclusions: In both obese and non-obese kidney transplant recipients, IBW had a stronger correlation with the therapeutic dose for LCPT. In addition, as BMI increased the therapeutic dose did not change, suggesting that IBW is the optimal weight to utilize in this population. Further pharmacokinetic studies are warranted to support these findings.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Breslin N, Jandovitz N, Nair V, Abate M, Teperman L. Comparing Weight-Based Dosing of Envarsus XR in Obese and Non-Obese Renal Transplant Recipients [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/comparing-weight-based-dosing-of-envarsus-xr-in-obese-and-non-obese-renal-transplant-recipients/. Accessed May 11, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences