Session Name: Kidney Acute Antibody Mediated Rejection
Session Date & Time: None. Available on demand.
*Purpose: The aim of this study is to investigate whether or not delayed graft function (DGF) and pre-transplant sensitization has a synergistic adverse effect on allograft outcome after deceased donor kidney transplantation (DDKT) using the Korean Organ Transplantation Registry (KOTRY) database, the nationwide prospective cohort.
*Methods: The study included 1,370 cases between May 2014 and June 2019. The cases were divided into 4 subgroups according to pre-sensitization and the development of DGF post-transplant (non-pre-sensitized-DGF(-) (n=1100), non-pre-sensitized-DGF(+)(n=133), pre-sensitized-DGF(-) (n=116), and pre-sensitized-DGF(+) (n=21)). We compared the incidence of biopsy-proven allograft rejection (BPAR), change in allograft function, allograft or patient survival, and post-transplant complications across 4 subgroups.
*Results: The incidence of overall BPAR and acute antibody-mediated rejection (ABMR) was significantly higher in the pre-sensitized-DGF(+) subgroup than in other 3 subgroups. In addition, multivariable analysis demonstrated that pre-sensitization combined with DGF is an independent risk factor for both overall BPAR and acute ABMR (hazard ratio 9.100, p < 0.001). Moreover, DGF and pre-sensitization showed significant interaction with each other (p for interaction < 0.001). Pre-sensitization combined with DGF did not show significant impact on allograft function, and allograft or patient survival.
*Conclusions: In conclusion, pre-sensitization and DGF had a synergistic adverse impact on allograft rejection after DDKT.
To cite this abstract in AMA style:Lee H, Park Y, Ban T, Song S, Song S, Yang J, Ahn C, Yang C, Chung B. Combined Impact of Pre-sensitization and Delayed Graft Function on Allograft Rejection in Deceased Donor Kidney Transplantation: A Nationwide Cohort Study [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/combined-impact-of-pre-sensitization-and-delayed-graft-function-on-allograft-rejection-in-deceased-donor-kidney-transplantation-a-nationwide-cohort-study/. Accessed June 12, 2021.
« Back to 2021 American Transplant Congress