Combined Impact of Pre-sensitization and Delayed Graft Function on Allograft Rejection in Deceased Donor Kidney Transplantation: A Nationwide Cohort Study
1Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s hospital, Seoul, Korea, Republic of, 2Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s hospital, Seoul, Korea, Republic of, 3Organ Transplantation Center and Department of Internal Medicine, Pusan National University Hospital, Pusan, Korea, Republic of, 4Department of Surgery, Ewha Womans University Medical Center, Seoul, Korea, Republic of, 5Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of
Meeting: 2021 American Transplant Congress
Abstract number: 1033
Keywords: Kidney transplantation, Rejection, Sensitization
Topic: Clinical Science » Kidney » Kidney Acute Antibody Mediated Rejection
Session Information
Session Name: Kidney Acute Antibody Mediated Rejection
Session Type: Poster Abstract
Session Date & Time: None. Available on demand.
Location: Virtual
*Purpose: The aim of this study is to investigate whether or not delayed graft function (DGF) and pre-transplant sensitization has a synergistic adverse effect on allograft outcome after deceased donor kidney transplantation (DDKT) using the Korean Organ Transplantation Registry (KOTRY) database, the nationwide prospective cohort.
*Methods: The study included 1,370 cases between May 2014 and June 2019. The cases were divided into 4 subgroups according to pre-sensitization and the development of DGF post-transplant (non-pre-sensitized-DGF(-) (n=1100), non-pre-sensitized-DGF(+)(n=133), pre-sensitized-DGF(-) (n=116), and pre-sensitized-DGF(+) (n=21)). We compared the incidence of biopsy-proven allograft rejection (BPAR), change in allograft function, allograft or patient survival, and post-transplant complications across 4 subgroups.
*Results: The incidence of overall BPAR and acute antibody-mediated rejection (ABMR) was significantly higher in the pre-sensitized-DGF(+) subgroup than in other 3 subgroups. In addition, multivariable analysis demonstrated that pre-sensitization combined with DGF is an independent risk factor for both overall BPAR and acute ABMR (hazard ratio 9.100, p < 0.001). Moreover, DGF and pre-sensitization showed significant interaction with each other (p for interaction < 0.001). Pre-sensitization combined with DGF did not show significant impact on allograft function, and allograft or patient survival.
*Conclusions: In conclusion, pre-sensitization and DGF had a synergistic adverse impact on allograft rejection after DDKT.
To cite this abstract in AMA style:
Lee H, Park Y, Ban T, Song S, Song S, Yang J, Ahn C, Yang C, Chung B. Combined Impact of Pre-sensitization and Delayed Graft Function on Allograft Rejection in Deceased Donor Kidney Transplantation: A Nationwide Cohort Study [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/combined-impact-of-pre-sensitization-and-delayed-graft-function-on-allograft-rejection-in-deceased-donor-kidney-transplantation-a-nationwide-cohort-study/. Accessed October 9, 2024.« Back to 2021 American Transplant Congress