ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Combined Heart–Kidney Compared to Isolated Heart Transplant in Patients with Chronic Kidney Disease – A Single Center Experience

D. Gauvin, A. Bhalla, W. McCallum, A. Vest, N. Goyal.

Tufts University School of Medicine, Boston, MA.

Meeting: 2018 American Transplant Congress

Abstract number: B62

Keywords: Graft function, Graft survival, Heart transplant patients, Kidney transplantation

Session Information

Session Name: Poster Session B: Heart and VADs: All Topics

Session Type: Poster Session

Date: Sunday, June 3, 2018

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Background:

Severe irreversible renal dysfunction has been a contraindication for heart transplant (HTx); however, combined heart-kidney transplant (HKTx) is an accepted therapeutic option for concomitant end stage heart and renal disease. Studies have compared the two modalities but data on HKTx versus HTx recipients with reduced GFR is sparse.

Methods:

We conducted a retrospective analysis comparing HTx recipients with GFR <45 ml/min/1.73 (Group 1, N = 32) to HKTx recipients (Group 2, N = 16) performed between January 2007 and June 2017 at a single center. Analysis was performed using SPSS version 23 (Chicago, IL).

Results:

Mean age was 59 and 54 years (p = 0.12) respectively, majority were male and caucasian. Other baseline characteristics are shown in Table 1.

Baseline Characteristics
Group 1 (HTx) Group 2 (HKTx) P Value
Ischemic Heart Disease- n (%) 12 (37) 8 (50) 0.54
LVEF- mean (SD) 12.6 (4.4) 16.8 (7.7) 0.05
MCSD- n (%) 26 (81) 7 (44) 0.02
Inotrope dependent- n (%) 16 (50) 13 (81) 0.06
Dialysis- n (%) 2 (6) 9 (56) <0.001
Baseline GFR excluding subjects on dialysis- mean (SD) 34.5 (7) 25.9 (3.6) 0.003
Pump Time- mean (SD) 196.6 (38.4) 183.1 (36) 0.22
Cardiac Ischemic Time- mean (SD) 198.8 (52.8) 191.2 (28.4) 0.58

Survival analysis evaluating cardiac allograft rejection and patient survival showed no significant difference in the 2 groups, but a trend towards lower rejection in Group 2.

Outcomes
Group 1 (HTx) Group 2 (HKTx) P Value
GFR Month 6- mean (SD) 37.4 (13.5) 58.9 (19.6) 0.002
GFR Year 1- mean (SD) 45.7 (16.6) 57.9 (20.7) 0.18
Median Follow Up (f/u)- days (interquartile range) 748 (1151) 882 (1929) 0.76
Mortality over f/u time- % 16 31 0.14
Rejection over f/u time- % 38 19 0.32
Hospital Length of Stay- mean (SD) 20.6 (11.8) 27.6 (23.3) 0.17

Conclusion:

HTKx provides similar patient and graft survival, lower cardiac rejection and higher GFR as compared to HTx in patients with reduced kidney function. The question of ideal GFR cut-off for combined heart-kidney transplantation needs further study.

CITATION INFORMATION: Gauvin D., Bhalla A., McCallum W., Vest A., Goyal N. Combined Heart–Kidney Compared to Isolated Heart Transplant in Patients with Chronic Kidney Disease – A Single Center Experience Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Gauvin D, Bhalla A, McCallum W, Vest A, Goyal N. Combined Heart–Kidney Compared to Isolated Heart Transplant in Patients with Chronic Kidney Disease – A Single Center Experience [abstract]. https://atcmeetingabstracts.com/abstract/combined-heart-kidney-compared-to-isolated-heart-transplant-in-patients-with-chronic-kidney-disease-a-single-center-experience/. Accessed June 6, 2025.

« Back to 2018 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences