Session Name: Poster Session B: Bacteria, Fungi, Parasites
Session Type: Poster Session
Date: Sunday, April 30, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Background: Clostridium difficile infection (CDI) data in intestinal transplant (ITx) recipients is lacking. This study was performed to evaluate prevalence, risk factors, treatments and outcomes of CDI in ITx recipients.
Methods: Retrospective study of adult and pediatric patients who underwent ITx (isolated or multi-visceral) between 1/2013 and 12/2015 at Jackson Memorial Hospital. Those who developed CDI within a year after ITx were considered cases. We evaluated if there were any differences in demographics, antibiotics or proton-pump inhibitors (PPI) use within 90 days prior and after ITx and one-year posttransplant survival between cases and controls. In addition, we assessed for severe CDI (WBC >15×103/mcl, creatinine >1.5 x baseline or pseudomembranes), CDI treatments and outcomes.
Results: 10/51 (20%) ITx recipients developed CDI. There were no differences in demographics, antibiotics or PPI use and one-year survival between groups [Table1]. The mean time from ITx to CDI diagnosis was 209±88.9 days. Four cases were severe. Vancomycin was given to two patients, and metronidazole and combined metronidazole/vancomycin to four each. None had colectomy, died from CDI or had recurrences within 12 weeks after being treated for CDI.
Conclusions: CDI was common in our ITx recipients and it was not associated with adverse outcomes. Larger studies are needed.
N[ordm] 10 (%)
N[ordm] 41 (%)
|3rdand 4thgeneration cephalosporins||8(80)||30(73)||>0.99|
|Number of days of antibiotics||31.6±11.3||50.4±41||0.16|
|≥ 2 groups of antibiotics||7(70)||27(66)||>0.99|
|Survival at one-year posttransplant||10(100)||30(73)||0.09|
CITATION INFORMATION: Goldenberg V, Berbel A, Camargo J, Simkins J. Clostridium difficile Infection in Intestinal Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Goldenberg V, Berbel A, Camargo J, Simkins J. Clostridium difficile Infection in Intestinal Transplant Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/clostridium-difficile-infection-in-intestinal-transplant-recipients/. Accessed January 28, 2023.
« Back to 2017 American Transplant Congress