ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Cinacalcet Versus Pre-Transplant Parathyroidectomy in Renal Transplant Recipients: Single Centre Experience.

G. Lucisano,1 R. Charif,1 K. Koutroutsos,1 D. Taube,1 F. Palazzo,2 M. Loucaidou.1

1Renal and Transplant Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom
2Centre for Endocrinology, Imperial College Healthcare NHS Trust, London, United Kingdom.

Meeting: 2016 American Transplant Congress

Abstract number: A249

Keywords: Bone, Graft function

Session Information

Date: Saturday, June 11, 2016

Session Name: Poster Session A: Long Term Outcomes in Kidney Transplantation

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Halls C&D

Related Abstracts
  • A Randomized Study Comparing Parathyroidectomy Versus Cinacalcet to Treat Hypercalcemia in Kidney Allograft Recipients With Persistent Hyperparathyroidism
  • Antibodies Are Not Necessarily Detrimental to the Graft Survival – Single Centre Experience in Living Donor Renal Transplantation

Introduction:Hyperparathyroidism(HPT) often persists after renal transplantation(Tx). Cinacalcet(Cx) and parathyroidectomy(PTx) are possible treatments. It was reported that PTx may be followed by a reduction in Tx function, raising the question whether it must be performed prior to Tx. In this retrospective study, we aimed to investigate the differences in several Tx outcome measures and in classical markers of bone homeostasis by comparing HPT patients who underwent PTx before Tx with patients whose HPT was managed medically.

Methods:130 Tx patients treated with Cx and 49 patients who underwent PTx before Tx were selected from our records over an 8-year period. We excluded patients with early (3 months) graft failure and a post-Tx follow up <6 months. The following 2-year post-Tx outcome measures were considered: graft failure, graft function (eGFR≥60mls/min), Tx artery stenosis requiring stenting within 12 months after Tx and rejection.

Results:117 and 46 patients were included in the Cx and PTx group respectively. PTH levels at the time of Tx were higher in the Cx vs PTx (72.3 vs 1.6,p<0.001). PTx was associated with significantly better bone profile markers (Ca 2.50 vs 2.36,p<0.001; Phos 0.85 vs 1.14,p<0.001; ALP 107 vs 80,p=0.004 at 24 months) during the study. No significant difference was found in rejection, renal artery stenosis and Tx failure rates between the two groups. The Cx group showed a better mean eGFR throughout the 24-month follow-up period (48.5±17.9 vs 39.9±17.8 at 24 months,p=0.015) compared to PTx group. This persisted after multivariant analysis (p=0.011). Investigating the hypothesis that such a finding could be explained by a longer HPT duration in the PTx group, we compared the latter with a subgroup of 48 patients who were already on Cx before Tx. The results were similar (p=0.015).

Conclusions:Tx patients with HPT who had PTx before Tx had significantly better bone profile markers up to 24 months after Tx compared with those treated with Cx. We observed better mean eGFR in the Cx compared to PTx group throughout the study. This may reflect the comorbidity of patients with more severe HPT in the PTx group since the difference in Tx function emerged in the first 3 months post-Tx and was due to causes such as infection and vascular complications. Further studies are required.

CITATION INFORMATION: Lucisano G, Charif R, Koutroutsos K, Taube D, Palazzo F, Loucaidou M. Cinacalcet Versus Pre-Transplant Parathyroidectomy in Renal Transplant Recipients: Single Centre Experience. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Lucisano G, Charif R, Koutroutsos K, Taube D, Palazzo F, Loucaidou M. Cinacalcet Versus Pre-Transplant Parathyroidectomy in Renal Transplant Recipients: Single Centre Experience. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/cinacalcet-versus-pre-transplant-parathyroidectomy-in-renal-transplant-recipients-single-centre-experience/. Accessed February 28, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.