Brain-Dead Donors Terminal Inflammation Is Associated to Delayed Graft Function in Kidney Transplant Recipients.
1Renal Transplant Unit, Hospital Clínic, Barcelona, Spain
2Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain
3Transplant Coordination Unit, Hospital Clínic, Barcelona, Spain
Meeting: 2017 American Transplant Congress
Abstract number: C19
Keywords: Brain death, Donation, Immunogenicity
Session Information
Session Name: Poster Session C: Deceased Donor Issues II: DCD, DGF, AKI, En-Bloc
Session Type: Poster Session
Date: Monday, May 1, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
BACKGROUND: in kidney transplantation recipients, increased biomarkers of systemic inflammation before and after the transplant are associated to worse short- and long-term renal outcomes. However, little is known about the role of systemic inflammation in the donor and if it is associated to worse graft outcomes.
MATHERIAL & METHODS: we retrospectively analyzed clinical and biochemical characteristics of all kidney brain-dead donors generated in our Hospital in the 2006-2015 period (n=194). Donors who were tested for C-Reactive Protein (CRP) in the 24 hours before BD declaration were included (n=97, 50%). Clinical and biochemical features of their respective recipients (n=165) were analyzed, comparing recipients who developed Delayed-Graft Function (DGF) (n=30) with recipients who did not (n=135).
RESULTS: in the univariate analysis, CRP was associated to DGF (p=0.025), along with dialysis vintage and RB score, while PRA, donor and recipients age/sex, ischemia time and terminal creatinine were not.
| No DGF (n=135) | DGF (n=30) | p-value | |
| RECIPIENT | |||
| Age (years) | 57 [46-64] | 57,5 [46,75-70] | 0,7 |
| Sex (%males) | 66,6% | 66,6% | 1 |
| Dialysis vintage (months) | 40 [25-63] | 58 [46,5-84,75] | 0,002 |
| PRA > 10% | 11/124 (8,1%) | 4/26 (13,3%) | 0,58 |
| Previous transplant (yes/no) | 28/107 (20.7%) | 9/21 (30%) | 0,39 |
| DONOR | |||
| Donor age (years) | 54,7 +/- 13,41 | 58,47 +/- 15, 46 | 0,18 |
| Donor sex (%males) | 51,8% | 60% | 0,54 |
| ECD (yes) | 78/135 (57,7%) | 20/30 (66.6%) | 0,48 |
| Donor CIT (hours) | 14 [11-18] | 15,5 [9,5-20,5] | 0,8 |
| Terminal creatinine (mg/dL) | 0,9 [0,67-1,1] | 1 [0,7-1,2] | 0,11 |
| Renal biopsy score | 3 [2-4] | 4 [2,25-4] | 0,021 |
| Donor CRP [mg/dL] | 4,81 [1,42-12,2] | 10,58 [5,1-18,21] | 0,025 |
However, in logistic regression analysis, PCR proved to be significant only in non-ECD donors (p=0.027), while it lost significance in the ECD group (p=0,76).
CONCLUSIONS: terminal donor CRP was associated to DGF in kidney transplant recipients and proved to be mostly significant in non-expanded criteria donors.
CITATION INFORMATION: Cucchiari D, Fritz D, Pedro V, Ramon A, David P, Jordi R, Frederic O, Ignacio R. Brain-Dead Donors Terminal Inflammation Is Associated to Delayed Graft Function in Kidney Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Cucchiari D, Fritz D, Pedro V, Ramon A, David P, Jordi R, Frederic O, Ignacio R. Brain-Dead Donors Terminal Inflammation Is Associated to Delayed Graft Function in Kidney Transplant Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/brain-dead-donors-terminal-inflammation-is-associated-to-delayed-graft-function-in-kidney-transplant-recipients/. Accessed November 21, 2024.« Back to 2017 American Transplant Congress