ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors

L. Fahmy, A. Massie, B. Orandi, S. Bagnasco, J. Alejo, B. Boyarsky, S. Anjum, R. Montgomery, N. Dagher, D. Segev.

Johns Hopkins, Baltimore.

Meeting: 2015 American Transplant Congress

Abstract number: 103

Keywords: Donation, Histology, Kidney

Session Information

Session Name: Concurrent Session: Kidney: Living Donor Issues I

Session Type: Concurrent Session

Date: Sunday, May 3, 2015

Session Time: 4:00pm-5:30pm

 Presentation Time: 5:12pm-5:24pm

Location: Terrace IV

Time-zero biopsies (T0-RBx) of live-donor kidneys may reveal histological abnormalities at the time of organ recovery. The association between T0-RBx and subsequent kidney function in live donors remains unknown.

METHODS: We abstracted % glomerulosclerosis (GS) and extent of interstitial fibrosis (IF) from T0-RBx of 220 live donors at our center and linked to donor estimated glomerular filtration rate (eGFR) obtained from post-donation medical records with median 7.2 years of followup time. We used multilevel mixed-effects linear regression to model the association between biopsy results and eGFR trajectory over time.

RESULTS: Median (IQR) GS was 4.8% (0%-9.7%). Minimal IF was observed in 72.5% and mild/moderate IF was observed in 27.6% of biopsies. In an age-unadjusted model with GS and IF, a 10% increase in GS was associated with eGFR decrease of 0.33 2.28 4.22 (p=0.02, Table 1). Mild/moderate IF (vs minimal) was associated with decreased eGFR (-7.48 -3.80 -0.13, p=0.03), but there was no evidence of association after adjustment for GS (-5.78 -1.82 2.14, p=0.4) (Table 1). Both GS and IF were statistically insignificant after adjusting for age (Table 1). Interaction terms were also statistically insignificant.

CONCLUSION: Mild GS in live donors was associated with decreased short-term post-donation eGFR; however this association disappeared after adjusting for age.

GS and IF models
  eGFR(mL/min/1.73m2 )
  Model 1 Model 2 Model 3 Model 4
Per year (0-10y) 0.670.961.25** 0.650.941.23** 0.670.961.25** 0.620.901.18**
Per year (>10y) -1.98-0.690.60 -1.98-0.690.60 -2.01-0.730.56 -2.06-0.780.51
GS (per 10%) -4.42-2.64-0.86**   -4.22-2.28-0.33 -2.62-0.850.91
Mild/Moderate IF (vs Minimal)   -7.48-3.80-0.13 -5.78-1.822.14 -4.53-1.002.53
Age (per 10y)       -6.88-5.45-4.02**
Bold = p<0.05; ** = p<0.001
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Fahmy L, Massie A, Orandi B, Bagnasco S, Alejo J, Boyarsky B, Anjum S, Montgomery R, Dagher N, Segev D. Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/association-between-histological-abnormalities-in-time-zero-renal-biopsies-and-post-donation-egfr-in-live-donors/. Accessed May 31, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences