Date: Monday, June 13, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Purpose: Delayed graft function (DGF) is associated with worse long-term outcomes after kidney transplantation from donation after brain death (DBD) donors. We aimed to determine whether this association held for transplantation from donation after circulatory death (DCD) donors.
Methods: Using data from the Australia and New Zealand Organ Donor (ANZOD) and Australia and New Zealand Dialysis and Transplant (ANZDATA) Registries, we included adult recipients of deceased donor kidney-only transplants in Australia and New Zealand over 2000-2014 (n=6748), excluding grafts with <7 days function (n=181). DGF was defined as the need for dialysis within 72h of transplantation. The relationship between DGF and death-censored graft survival was examined in a Cox model adjusted for donor, transplant and recipient factors.
Results: DGF occurred in 22% of DBD and 55% of DCD transplants (p<0.001). On unadjusted analysis DGF was associated with worse death-censored graft survival in both DBD and DCD donors. After adjusting for confounders, the hazard ratio (HR) (95% CI) for DGF was 1.32 (1.11, 1.58) in DBD transplants and 1.77 (0.87, 3.58) in DCD transplants (interaction HR 1.34 (0.65, 2.77), p=0.11).
Conclusions: DGF was associated with worse death-censored graft survival in both DBD and DCD kidney transplants, with no statistically significant difference in the magnitude of this association between DBD and DCD transplants.
CITATION INFORMATION: Clayton P, Russ G, McDonald S, Chadban S. Association Between Delayed Graft Function and Long-Term Outcomes After Kidney Transplantation from Donors After Circulatory Death. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Clayton P, Russ G, McDonald S, Chadban S. Association Between Delayed Graft Function and Long-Term Outcomes After Kidney Transplantation from Donors After Circulatory Death. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/association-between-delayed-graft-function-and-long-term-outcomes-after-kidney-transplantation-from-donors-after-circulatory-death/. Accessed December 2, 2020.
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