Association Between Delayed Graft Function and Long-Term Outcomes After Kidney Transplantation from Donors After Circulatory Death.

P. Clayton,^1,2,3 G. Russ,^1,2,3 S. McDonald,^1,2,3 S. Chadban.^1,4,5

¹Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, Royal Adelaide Hospital, Adelaide, SA, Australia
²Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia
³School of Medicine, University of Adelaide, Adelaide, SA, Australia
⁴Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia
⁵Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Meeting: 2016 American Transplant Congress

Abstract number: C189

Keywords: Donors, Graft failure, Kidney transplantation, non-heart-beating

Session Information

Session Name: Poster Session C: Kidney Transplantation: AKI/Preservation/DCD

Session Type: Poster Session

Date: Monday, June 13, 2016

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Purpose: Delayed graft function (DGF) is associated with worse long-term outcomes after kidney transplantation from donation after brain death (DBD) donors. We aimed to determine whether this association held for transplantation from donation after circulatory death (DCD) donors.

Methods: Using data from the Australia and New Zealand Organ Donor (ANZOD) and Australia and New Zealand Dialysis and Transplant (ANZDATA) Registries, we included adult recipients of deceased donor kidney-only transplants in Australia and New Zealand over 2000-2014 (n=6748), excluding grafts with <7 days function (n=181). DGF was defined as the need for dialysis within 72h of transplantation. The relationship between DGF and death-censored graft survival was examined in a Cox model adjusted for donor, transplant and recipient factors.

Results: DGF occurred in 22% of DBD and 55% of DCD transplants (p<0.001). On unadjusted analysis DGF was associated with worse death-censored graft survival in both DBD and DCD donors. After adjusting for confounders, the hazard ratio (HR) (95% CI) for DGF was 1.32 (1.11, 1.58) in DBD transplants and 1.77 (0.87, 3.58) in DCD transplants (interaction HR 1.34 (0.65, 2.77), p=0.11).

Conclusions: DGF was associated with worse death-censored graft survival in both DBD and DCD kidney transplants, with no statistically significant difference in the magnitude of this association between DBD and DCD transplants.

CITATION INFORMATION: Clayton P, Russ G, McDonald S, Chadban S. Association Between Delayed Graft Function and Long-Term Outcomes After Kidney Transplantation from Donors After Circulatory Death. Am J Transplant. 2016;16 (suppl 3).

To cite this abstract in AMA style:

Clayton P, Russ G, McDonald S, Chadban S. Association Between Delayed Graft Function and Long-Term Outcomes After Kidney Transplantation from Donors After Circulatory Death. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/association-between-delayed-graft-function-and-long-term-outcomes-after-kidney-transplantation-from-donors-after-circulatory-death/. Accessed November 22, 2024.

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