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Accomplishment of Ischemia-Free Kidney Transplantation Using Normothermic Machine Perfusion

G. Chen, X. He, C. Wang, X. Yuan, M. Han, Z. Guo

Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

Meeting: 2020 American Transplant Congress

Abstract number: D-207

Keywords: Ischemia, Kidney transplantation, Machine preservation

Session Information

Session Name: Poster Session D: Non-Organ Specific: Organ Preservation/Ischemia Reperfusion Injury

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT).

*Methods: The kidney graft was donated by a 19-year-old brain dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved and implanted without cessation of blood supply using normothermic machine perfusion.

*Results: The graft appearance, perfusion flow and urine production suggested the kidney was functioning well during the whole procedure. The creatinine dropped rapidly to normal range within three days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection, vascular or infectious complications occurred.

*Conclusions: This paper marks the first case of IFKT in humans. This innovation might offer a unique solution to optimize transplant outcomes in kidney transplantation.

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To cite this abstract in AMA style:

Chen G, He X, Wang C, Yuan X, Han M, Guo Z. Accomplishment of Ischemia-Free Kidney Transplantation Using Normothermic Machine Perfusion [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/accomplishment-of-ischemia-free-kidney-transplantation-using-normothermic-machine-perfusion/. Accessed May 11, 2025.

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