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“A New Lease on Life”: Patient Perceptions After Early Liver Transplantation for Alcohol-Related Liver Disease

R. Greenberg, G. Punchhi, H. Sung, K. Gianaris, M. Krach, K. Herrick-Reynolds, P. Chen, M. Levan, J. Garonzik Wang, A. Cameron

Johns Hopkins, Baltimore, MD

Meeting: 2021 American Transplant Congress

Abstract number: 709

Keywords: Alcohol, Liver, Liver transplantation

Topic: Clinical Science » Ethics » Psychosocial and Treatment Adherence

Session Information

Session Name: Psychosocial and Treatment Adherence

Session Type: Poster Abstract

Session Date & Time: None. Available on demand.

Location: Virtual

*Purpose: At some centers, alcohol-related liver disease (ARLD) patients, who are unlikely to survive six months without a liver transplant (LT), are selected to receive life-saving early liver transplantation (ELT) despite zero to minimal sobriety. ELT recipients’ perceptions of their LT experiences have not been previously examined and can help inform ARLD transplant policies.

*Methods: We conducted a preliminary thematic analysis of in-depth semi-structured interviews with 17 ELT recipients transplanted between December 2013 and July 2020, at a single center. Interviews focus on the ELT experience, alcohol use, and the six-month wait period guideline and will continue until thematic saturation is reached.

*Results: A common participant perception was feeling thankful for a new liver. Participants expressed various motivations for taking care of their new livers and their health, characterizing the transplant as a “new lease on life.” Participants described their changed attitudes towards alcohol post-LT and disclosed ongoing challenges, such as maintaining sobriety, “fighting” for self-identity, navigating stressors, and redefining their relationships. Regarding the six-month wait period, participants expressed a range of perspectives, from beliefs that a guideline may be helpful in some cases to criticisms that the guideline groups patients into “black and white categor[ies]” and ignores their circumstances. Participants discussed the stigma of being perceived as an “alcoholic” and highlighted the struggle of trying to demonstrate sobriety while dealing with a “dead liver.” Participants expressed a desire for specific supports for ARLD LT patients.

*Conclusions: ELT recipients’ perceptions illuminate the struggles and stigma associated with ARLD, as well as the direct impact of the six-month wait period on ARLD patients in need of an LT. These findings can help inform an ethical and evidence-based policy for transplanting ARLD patients.

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To cite this abstract in AMA style:

Greenberg R, Punchhi G, Sung H, Gianaris K, Krach M, Herrick-Reynolds K, Chen P, Levan M, Wang JGaronzik, Cameron A. “A New Lease on Life”: Patient Perceptions After Early Liver Transplantation for Alcohol-Related Liver Disease [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/a-new-lease-on-life-patient-perceptions-after-early-liver-transplantation-for-alcohol-related-liver-disease/. Accessed May 9, 2025.

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