Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Both amyloid light chain (AL) amyloidosis and transthyretin-related (TTR) amyloid are expanding indications for heart transplantation (HTx). In the past, AL amyloid, in particular, had been a contraindication to HTx given its systemic nature and the increased risk for mortality. Modern treatments including proteasome inhibitors have allowed amyloid patients to receive heart transplants at an increasing rate. We sought to assess long-term post-transplant outcome in amyloid patients in the current era.
*Methods: Between 2010 and 2015, we assessed 27 patients (5 AL, 10 TTR-wildtype (wt), 12 TTR-mutant (m)) who underwent heart transplant for cardiac amyloidosis at our single center. A non-amyloid restrictive cardiomyopathy control population was included (n=18). Endpoints included 3-year outcomes including survival, freedom from CAV (as defined by stenosis ≥ 30% by angiography), freedom from non-fatal major adverse cardiac events (NF-MACE: myocardial infarction, new congestive heart failure, percutaneous coronary intervention, implantable cardioverter defibrillator/pacemaker implant, stroke), and freedom from any-treated rejection, acute cellular rejection, and antibody-mediated rejection.
*Results: There was no significant difference between the AL amyloid, TTR-wt, TTR-m, and restrictive non-amyloid patients with respect to 3-year survival and 3-year freedom from CAV, NF-MACE, and rejection (see table). Endomyocardial biopsies post-transplant did not show amyloid.
*Conclusions: In the current era, both AL and TTR amyloid patients have acceptable mid-term outcome after heart transplantation. Larger numbers and longer followup are needed to confirm these findings.
|Endpoints||AL (n=5)||TTR wt senile (n=10)||TTR mutant (n=12)||Non-Amyloid Restrictive Control (n=18)||Log-Rank P-Value|
|3-Year Freedom from CAV||80.0%||80.0%||83.3%||88.9%||0.990|
|3-Freedom from NF-MACE||100.0%||90.0%||75.0%||100.0%||0.112|
|3-Freedom from Any-Treated Rejection||100.0%||100.0%||91.7%||94.4%||0.619|
|3-Year Freedom from Acute Cellular Rejection||100.0%||100.0%||91.7%||100.0%||0.518|
|3-Year Freedom from Antibody-Mediated Rejection||100.0%||100.0%||100.0%||94.4%||0.367|
To cite this abstract in AMA style:Patel J, Kittleson M, Chang DH, Levine R, Dimbil S, Czer L, Esmailian F, Kobashigawa JA. 3-year Outcome Of Heart Transplantation In Patients With Amyloidosis [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/3-year-outcome-of-heart-transplantation-in-patients-with-amyloidosis/. Accessed July 24, 2021.
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