Comparison of Markers of Inflammation Between Dialysis Patients With and Without Failed Kidney Allograft
Nephrology and Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, DF, Mexico.
Meeting: 2015 American Transplant Congress
Abstract number: B107
Keywords: Graft failure, Inflammation, Renal failure
Session Information
Session Name: Poster Session B: Kidney Complications: Late Graft Failure
Session Type: Poster Session
Date: Sunday, May 3, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
BACKGROUND: The rates of morbidity and mortality in patients with a failed kidney transplant are higher than dialysis patients who had never been transplanted. The aim of this study was to establish if there is any difference in inflammatory status between patients on dialysis with non-functional graft versus non-transplanted patients.
METHODS: Case-control study. Cases were patients with retained non-functional graft, without surgical procedures or infections during previous 2 months. Control cases were paired by age, gender, ESRD etiology, and time on dialysis. Cytokines were measured by luminometry (Luminex). Ultrasensitive C-reactive protein was determinate by ELISA. Chi Square test, Student T test, and Mann-Whitney U test were used.
RESULTS: A total of 44 cases and 70 controls were included. The characteristics are showed in Table.
| VARIABLE | Failed Graft (n=44) | Controls (n=70) | p |
| Age | 34.5±9.8 | 35.3±11.8 | 0.703 |
| Time on dialysis (years) | 2.82 (0.4-19.5) | 3.13 (0.53-12.8) | 0.817 |
| BMI | 22.7 ± 3.2 | 25.02 ± 4.5 | 0.002 |
| Cholesterol (mg/dL) | 130.2 ± 59.8 | 152.6 ± 61.9 | 0.059 |
| Albumin (mg/dL) | 4.08 ± 0.6 | 4.29 ± 0.5 | 0.054 |
| Hemoglobin (g/dL) | 9.3±1.9 | 11.1±2.4 | 0.000 |
| EPO dose (UI/w) | 9024 ± 4486 | 6126 ± 5458 | 0.006 |
| Ferritin (ng/mL) | 292.1 (11-3201) | 208.2 (8-1950) | 0.044 |
| PTHi (pg/mL) | 577.3 ± 603 | 665.9 ± 495.7 | 0.430 |
CONCLUSION: Patients with renal graft nonfunctional have a trend to develop a state of chronic inflammation, expressed in the cytokine profile exposed. The Failed Kidney Graft group showed a lower levels of albumin, cholesterol, hemoglobin, BMI and a higher requirement of EPO, maybe related to inflamation.
To cite this abstract in AMA style:
Villca-Gonzales R, Vazquez-Apodaca R, Hernandez-Ramirez D, Llorente-Peters L, Alberu J, Morales-Buenrostro L. Comparison of Markers of Inflammation Between Dialysis Patients With and Without Failed Kidney Allograft [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-markers-of-inflammation-between-dialysis-patients-with-and-without-failed-kidney-allograft/. Accessed November 24, 2024.« Back to 2015 American Transplant Congress