Relations Among Hyperuricemia, Inflammation, Oxidative Stress and Arterial Stiffness in Renal Transplant Recipients
1Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey
2Department of Nephrology, Baskent University Faculty of Medicine, Istanbul, Turkey
3Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.
Meeting: 2015 American Transplant Congress
Abstract number: A184
Keywords: Arteriosclerosis, Inflammation, Metabolic complications, Oxidant stress
Session Information
Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic
Session Type: Poster Session
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Purpose: Uric acid is the end product of purine metabolism and has well known anti-oxidant effects. Superoxide dismutase (SOD) and malondialdehyde (MDA) are well-known antioxidant enzymes that detoxifies highly oxidant compounds as advanced glycation end products (AGE). The aim of this study was to evaluate the relationships between serum uric acid levels, inflammation and oxidative stress parameters accompanied by arterial stiffness in renal transplant recipients.
Materials and Methods: Fifthy renal transplant recipients (36 male, mean age: 39.2 years) with stable allograft function from our renal transplant outpatient clinic were enrolled into the study. All acute cellular and humoral rejections were excluded. According to mean serum uric acid (sUA) levels patients were divided into 2 groups as group 1 (sUA > 6 mg/dl; n: 25) and group 2 (sUA <6 mg/dl; n: 25). All patients were evaluated for their standard clinical (age, gender, duration of hemodialysis, post-transplant time), biochemical parameters (serum uric acid, C-reactive protein [CRP], albumin), serum AGE, MDA, SOD, FGF-23 and Klotho levels were determined by ELISA method. Pulse wave velocity (PWv) was determined from pressure tracing over carotid and femoral arteries using the SphygmoCor system.
Results: Groups were similar in means of clinical and demographic characteristics. Patients in group 1 had significantly higher CRP (p: 0.031), PWv (p: 0.006), AGE (p: 0.002), FGF-23 (p: 0.001) levels, however significantly lower eGFR (p: 0.024) and MDA levels (p: 0.031). For each 1 mg/dL of increased level of sUA resulted in 0.162 cm/sec of increased level of PWv (p: 0.05, CI: -0.006 – 0.330) and 0.003 pg/ml of FGF-23 (p: 0.05, CI: 0.000- 0.007). In linear regression analysis, serum MDA (p: 0.027) and FGF-23 levels (p: 0.004) were detected as the predictors of PWv.
Conclusion: We concluded that hyperuricemia was correlated with increased levels of CRP, AGE and FGF-23 levels, and decreased levels of eGFR and MDA. Thus reduction in uric acid levels might contribute to improve allograft function and cardiovascular morbidity and mortality in kidney transplant recipients.
To cite this abstract in AMA style:
Demirci BGurlek, Sezer S, Uyar MErkmen, Bal Z, Tutal E, Acar FOzdemir, Haberal M. Relations Among Hyperuricemia, Inflammation, Oxidative Stress and Arterial Stiffness in Renal Transplant Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/relations-among-hyperuricemia-inflammation-oxidative-stress-and-arterial-stiffness-in-renal-transplant-recipients/. Accessed November 24, 2024.« Back to 2015 American Transplant Congress