Safety and Immunogenicity of BNT-162b2 versus Chadox1 Vaccine in Solid Organ Transplant Recipients: Prospective Study

A. Ajlan¹, T. Ali², H. Aleid², K. Almeshari², M. Alkaff³, S. Althuwaidi⁴, L. Fajji², A. Alali⁵, D. Halabi⁶, A. Ullah⁷, K. H. Marquez⁸, B. Elmikkaoui⁹, A. Alrajhi¹⁰, A. Zidan¹¹, E. Albogumi.¹², K. Bzeizi¹³, R. Almaghrabi¹⁴, E. DeVol¹⁵, M. Al-Awwami,¹⁶, S. Alghamdi¹³, P. Broering²

¹Pharmaceutical Care Division - Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riaydh, Saudi Arabia, ²Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ³Medical Laboratory, KFSHRC, Riaydh, Saudi Arabia, ⁴Medical Microbiology, KFSHRC, Riaydh, Saudi Arabia, ⁵Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁶Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁷Kidney & Pancreas Health Centre, KFSHRC, Riaydh, Saudi Arabia, ⁸Analytics Data Centre - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁹Data Management - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁰Infectious Diseases - Medicine Department, KFSHRC, Riaydh, Saudi Arabia, ¹¹Abdominal Transplant & Hepatobiliary Surgery Centre, KFSHRC, Riaydh, Saudi Arabia, ¹²Data Management. - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹³Liver & Small Bowel Health Centre, KFSHRC, Riaydh, Saudi Arabia, ¹⁴Infectious Diseases - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁵Biostatistics, Epidemiology &Scientific Computing, KFSHRC, Riaydh, Saudi Arabia, ¹⁶Histocompatibility and Immunogenetics Laboratory Kidney & Pa - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia

Meeting: 2022 American Transplant Congress

Abstract number: 1657

Keywords: COVID-19, Kidney transplantation, Liver transplantation, Vaccination

Topic: Clinical Science » Pharmacy » 30 - Non-Organ Specific: Clinical Pharmacy/Transplant Pharmacotherapy

Session Information

Session Name: Pharmacy II

Session Type: Poster Abstract

Date: Tuesday, June 7, 2022

Session Time: 7:00pm-8:00pm

Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: Data showed seroconversion after different SARS-CoV-2 vaccination platforms might yield diminished response in transplant recipients. However, it is unknown whether different vaccination platforms could offer a specific grade of protection against SARS-CoV-2.

*Methods: we prospectively studied adult kidney & liver recipients who received who had no previous COVID-19 infection, and received either ChAdOx1 or BNT-162b2 vaccines between January 2021 to September 2021, with an assessment of IgM/IgG spike (S) antibodies.

*Results: Our cohort is composed of kidney (n=235) or liver (n=217) patients, who have received either ChAdOx1 (N=157) or BNT-162b2 (n=295). The response was higher with mRNA vaccine. Unresponsiveness is found to be mainly linked to diabetes and older age. Side effects were similar to those reported in clinical trials.

*Conclusions: mRNA vaccines might elicit a higher humoral immunity response as compared with ChAdOx1 in immunosuppressed transplant patients.

To cite this abstract in AMA style:

Ajlan A, Ali T, Aleid H, Almeshari K, Alkaff M, Althuwaidi S, Fajji L, Alali A, Halabi D, Ullah A, Marquez KH, Elmikkaoui B, Alrajhi A, Zidan A, Albogumi E, Bzeizi K, Almaghrabi R, DeVol E, Al-Awwami M, Alghamdi S, Broering P. Safety and Immunogenicity of BNT-162b2 versus Chadox1 Vaccine in Solid Organ Transplant Recipients: Prospective Study [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/safety-and-immunogenicity-of-bnt-162b2-versus-chadox1-vaccine-in-solid-organ-transplant-recipients-prospective-study/. Accessed November 21, 2024.

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