*Purpose: The aim of this prospective study was to evaluate the influence of frailty on depression, anxiety and health-related quality of life for patients on the waitlist for liver transplantation.

*Methods: Between September 2015 and November 2019 all patients listed for liver transplantation were included to the study. Fried Frailty criteria were assessed. Validated standard questionnaires/tests were used for the assessment of depression, anxiety and health related quality of life. All tests were repeated every six months and 12 months after transplantation. Prä-, intra and postoperative data were reported, as well

*Results: Total of 114 patients in median age of 53 years were included to the study. Non-frail were 27 patients (23.7%), pre-frail 58 patients (50.9%) und frail 29 patients (25.4%). The comparison of the psychometric factors between the three groups has shown, that anxiety and depression was seen significantly more often in pre-frail or frail patients (p< 0.001). The health-related quality of life was significantly better in none-frail patients (p< 0.001). During this timeframe 62 patients (54.4%) underwent liver transplantation. Number of pre-frail and frail patients with depression was postoperatively decreased but not significantly. Number of patients with anxiety was significantly decreased after LT. The health related quality of life has not changed 6 months after LT. There was no significant correlation between frailty and psychometric factors postoperatively.

*Conclusions: Rate of depression and anxiety is significantly higher in frail patients on waitlist for liver transplantation. Psychological support/treatment of these patients on waitlist seems to be useful. Although patients need more than 6 months after transplantation for recovery of life qualitity and depression, however anxiety improves right after successfull liver transplantation.

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