HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation
1Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
2Bezmialem Vakif University, Experimental Research Center, Istanbul, Turkey
3Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Immunology, Istanbul, Turkey
4Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey
5Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey
6Bezmialem Vakif University, Faculty of Medicine, Department of Biophysics, Istanbul, Turkey
7Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey
8Bezmialem Vakif University, Institute of Life Sciences and Biotechnology, Istanbul, Turkey
9Bezmialem Vakif University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey.
Meeting: 2018 American Transplant Congress
Abstract number: C10
Keywords: Donors, HLA matching, Major histocompatibility complex (MHC), unrelated
Session Information
Session Name: Poster Session C: Histocompatibility and Immunogenetics
Session Type: Poster Session
Date: Monday, June 4, 2018
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Permanent hypoparathyroidism(PH) is incurable condition and requires life long drug therapy.Unique therapeutic option is parathyroid allotransplantation(PA).Some studies use routinely but emprically HLA typing,PRA(panel reactive antibody) and DSA(donor specific antigen) screening tests before PA.In this research we aimed to evaluate the effectiveness of HLA,PRA and DSA for success of PA.We performed PA to unrelated four recipients from one living donor.HLA typing,PRA and DSA levels were observed.Recipients were discharged from the hospital without any complications and observed throughout four years.Two out of four PAs were successful.No correlations were observed for the success of transplantation about the tests of HLA typing,PRA and DSA(Table 1).In conclusion HLA typing,PRA and DSA tests were not necessary for PA.
Table 1. Comparision of pre-/post-transplant results. Rcp:Recipient
| HLA-A | HLA-B | HLA-C | HLA-DRB1 | HLA-DQB1 | |
| Donor | A*26 /A*32 | B*14 /B*44 | C*05 / C*08 | B1*01 /B1*04 | B1*03 / B1*05 |
| Rcp 1 | A*11 /A*24 | B*44 /B*51 | C*04 / C*07 | B1*13 /B1*13 | B1*06 / B1*06 |
| Rcp 2 | A*02 /A*68 | B*18 / B*51 | C*07 / C*15 | B1*11 /B1*11 | B1*03 / B1*03 |
| Rcp 3 | A*01 /A*32 | B*08 / B*57 | C*06 / C*07 | B1*03 /B1*03 | B1*02 / B1*02 |
| Rcp 4 | A*02 /A*02 | B*51 / B*51 | C*07 / C*15 | B1*11 /B1*16 | B1*03 / B1*05 |
CITATION INFORMATION: Kanimdan E., Goncu B., Gelmez Y., Idiz O., Toka C., Ozdemir B., Basoglu H., Ozten Kandas N., Yucesan E., Ersoy Y., Kazancioglu R., Aysen E. HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Kanimdan E, Goncu B, Gelmez Y, Idiz O, Toka C, Ozdemir B, Basoglu H, Kandas NOzten, Yucesan E, Ersoy Y, Kazancioglu R, Aysen E. HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation [abstract]. https://atcmeetingabstracts.com/abstract/hla-typing-panel-reactive-antibody-and-donor-specific-antigen-tests-are-not-necessary-for-successful-parathyroid-allotransplantation/. Accessed November 23, 2024.« Back to 2018 American Transplant Congress