Pancreatic Graft Loss after Simultaneous Pancreas Kidney (SPK) Transplant within First 90 Days. Predictors beyond the Surgical Cause. A UNOS/OPTN Data Analysis
Multi-Organ Transplantation Unit, University of Western Ontario, London, ON, Canada.
Meeting: 2018 American Transplant Congress
Abstract number: A365
Keywords: Graft failure, Pancreas
Session Information
Session Name: Poster Session A: Pancreas and Islet: All Topics
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Background: Data on causal effects of variables to predict the early pancreatic graft loss in first 90 days is limited.
Aim: To predict the early pancreatic graft loss between 30 -90 days post SPK transplant by assessing the interaction of the variates.
Methods: SPK recipients with pancreas graft loss 03 months post SPK transplant were analysed from UNOS/OPTN database (1999-2015). Patients with graft loss within first 30 days were excluded from analysis to minimize the bias of surgical causes to graft loss.
Results: N=672 (DCD -168; DBD – 504) pancreas were lost within 30-90 days. DCD transplant, donor age >25 years, recipient age > 30 years, donor BMI> 30, recipient BMI>30, pancreas preservation time >4 hr, cold ischemia time >12 hr andrenal Tx rejection with first 30 days were independent predictors on univatiate analysis. (p<0.05). A hierarchical multiple regression was run to determine if the addition of donor BMI> 30, recipient BMI>30 improved the prediction of Graft loss at 90 days over and above DCD transplant, donor age >25 years, recipient age > 30 years alone. The full model of DCD transplant, donor age >25 years, recipient age > 30 years, donor BMI> 30, recipient BMI>30, pancreas preservation time >4 hr, cold ischemia time >12 hr and kidney transplant rejection with first 30 days to predict Pancreatic Graft loss at 90 days was statistically significant, p < .0001; adjusted R2 = 0.610. 
The assumption of normality was met-(QQ Plot ). 
Conclusions: Predictors determined by univariate analysis can affect the graft loss at 90 days but overall pooled interaction of predictors maximally influences the probability of pancreatic graft loss at 90 days post transplant.
CITATION INFORMATION: Sharma H., Abraham M., Chen J., Mikhail D., Aquil S., Patel S., Skaro A., McAlister V., Sener A., Luke P. Pancreatic Graft Loss after Simultaneous Pancreas Kidney (SPK) Transplant within First 90 Days. Predictors beyond the Surgical Cause. A UNOS/OPTN Data Analysis Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Sharma H, Abraham M, Chen J, Mikhail D, Aquil S, Patel S, Skaro A, McAlister V, Sener A, Luke P. Pancreatic Graft Loss after Simultaneous Pancreas Kidney (SPK) Transplant within First 90 Days. Predictors beyond the Surgical Cause. A UNOS/OPTN Data Analysis [abstract]. https://atcmeetingabstracts.com/abstract/pancreatic-graft-loss-after-simultaneous-pancreas-kidney-spk-transplant-within-first-90-days-predictors-beyond-the-surgical-cause-a-unos-optn-data-analysis/. Accessed November 21, 2024.« Back to 2018 American Transplant Congress