Prospective Monitoring of 25-Hydroxyvitamin Vitamin D Levels After Kidney Transplantation and Its Associations with Clinical Outcomes.
Montefiore Transplant Center, Albert Einstein College of Medicine, Bronx, NY
Meeting: 2017 American Transplant Congress
Abstract number: D262
Keywords: Graft failure, Kidney transplantation, Metabolic disease, Outcome
Session Information
Session Name: Poster Session D: Long Term Kidney Outcomes
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Background: Kidney transplant recipients usually have low vitamin D levels. Vitamin D deficiency is recognized as a risk factor for progression of kidney disease in general population. However, its association with graft outcomes in renal transplant patients is not well established.
Methods: We measured 25-hydroxyvitamin (OH) D levels at 6, 12, 24 and 36 months post-transplant in patients transplanted at our center between Jan 2009 and Dec 2014 and investigated the association between 25-OH-vit D levels at 6 months post-transplant and clinical outcomes.
Results: Prevalence of 25-OH-vit D levels <15, 15-19.9, 20-29.9, and > 30 ng/ml, was (29.2%, 22.2%, 34.7%, 13.3%) at 6 months, (21.4%, 23.7%, 35.0%, and 19.7%) at 1 year, (14.9%, 21.9%, 41.3%, 21.8%) at 2 years, and (16.8%, 18.5%, 38.5%, 26.2%) at 3 years, respectively. A total of 383 patients were followed up for 3.8 (2.4-5.3) years. There was no difference between the 4 groups in terms of age, sex, race, type of transplant, KDPI score, PRA levels, pretransplant DSA, and type of induction. Lower 25-OH-vit D levels increased risk of graft loss and difference was significant (p = 0.038) by Kaplan-Meier survival, even though other allograft outcomes including acute antibody or T cell mediated rejection, transplant glomerulopathy/chronic rejection, development of de novo DSA, incidence of CMV, BKV and fungal infections, malignancy, proteinuria at 1 and 3 years post-transplant, and serum creatinine levels were found to be similar.
Conclusions: 25-OH-vit D deficiency is common after kidney transplantation and low 6 months post renal transplant 25-OH-vit D levels were associated with inferior allograft survival. Randomized trials will be needed to delineate if vitamin D replacement would improve long term graft outcomes. 
CITATION INFORMATION: Bedi P, Hayde N, Kamal L, Ajaimy M, Lubetzky M, de Boccardo G, Akalin E. Prospective Monitoring of 25-Hydroxyvitamin Vitamin D Levels After Kidney Transplantation and Its Associations with Clinical Outcomes. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Bedi P, Hayde N, Kamal L, Ajaimy M, Lubetzky M, Boccardo Gde, Akalin E. Prospective Monitoring of 25-Hydroxyvitamin Vitamin D Levels After Kidney Transplantation and Its Associations with Clinical Outcomes. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/prospective-monitoring-of-25-hydroxyvitamin-vitamin-d-levels-after-kidney-transplantation-and-its-associations-with-clinical-outcomes/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress