Semi-Automated Pre-Donation Computed Topography (CT) Cortical Renal Volume to Predict Kidney Function in Live Kidney Donors 2 Years Following Donation.
1Transplant Nephrology, UC Davis Medical Center, Sacramento, CA
2Radiology, UC Davis Medical Center, Sacramento, CA
3Biostatistics, UC Davis School of Medicine, Davis, CA
4Transplant Surgery, UC Davis Medical Center, Sacramento, CA
Meeting: 2017 American Transplant Congress
Abstract number: D236
Keywords: Age factors, Glomerular filtration rate (GFR), Kidney transplantation, Renal function
Session Information
Session Name: Poster Session D: Living Donor Kidney Transplant II
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Objective: To evaluate whether volume of the remnant kidney based on pre-donation CT and donor age correlates with post-donation 2-year renal function in live kidney donors.
Materials and methods: In this retrospective single-center study, 51 live kidney donors were identified who underwent pre-donation CT and had an estimated glomerular filtration (eGFR) determination at 2 years post donation. Age, retained kidney whole and cortical volumes, and eGFR at 2 years post donation were recorded. Donor eGFR<60 ml/min/1.73m2at 2 years post-donation was used as cut-off value. Pearson correlation coefficients (PCC) evaluated the relationship of age and retained volume/BMI ratio with 2-year eGFR, and logistic regression models for those factors significantly associated with a2-year eGFR<60 were created. Optimal cut-points were identified, and models using these were created to predict eGFR<60 at the end of 2 years.
Results: Retained cortical volume/BMI ratio (CV/BMI) was the normalized volume measurement most strongly associated with the 2-year eGFR (PCC=0.66). CV/BMI and age were associated with 2-year eGFR<60 in a logistic regression model (p=0.02 and <0.01, respectively). The area under the receiver-operator curve for a model that included CV/BMI and age was 0.9. Optimal cut-points to predict eGFR≥60 at 2 years were age<45 years and CV/BMI≥4.5 mL/(kg/m2). If both risk factors were unfavorable (age>45 years and CV/BMI<4.5), the probability of a 2-year eGFR<60 estimated by the model was 92%. If both did not meet the age and BMI thresholds (age<45 years and CV/BMI≥4.5), the probability was 3%. If only one factor was favorable (age<45 years or CV/BMI≥4.5), the probability was 36 or 39%, respectively. (Table 1)
Conclusion: Pre-donation CT CV/BMI ratio of the remnant kidney and age are important factors inpredicting eGFR<60 in donors 2 years post donation and may thus provide important decision support during the live donor selection process.
Table 1 Probability of 2-year GFR < 60 ml/min/1.73m2based on age and normalized cortical volume
| CV/BMI ≥ 4.5 mL/(kg/m2) | CV/BMI < 4.5 mL/(kg/m2) | |
| Age < 45 | 3% | 36% |
| Age>45 | 39% | 92% |
CITATION INFORMATION: Chen L.-X, Fananapazir G, Benzl R, Corwin M, Stewart S, Troppmann C. Semi-Automated Pre-Donation Computed Topography (CT) Cortical Renal Volume to Predict Kidney Function in Live Kidney Donors 2 Years Following Donation. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Chen L-X, Fananapazir G, Benzl R, Corwin M, Stewart S, Troppmann C. Semi-Automated Pre-Donation Computed Topography (CT) Cortical Renal Volume to Predict Kidney Function in Live Kidney Donors 2 Years Following Donation. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/semi-automated-pre-donation-computed-topography-ct-cortical-renal-volume-to-predict-kidney-function-in-live-kidney-donors-2-years-following-donation/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress